indeloxazine

RN given refers to parent cpd without isomeric designation

Also Known As:

2-(7-indenyloxymethyl)morpholine; AS1069562; YM 08054-1; YM-08054-1; indeloxazine hydrochloride; indeloxazine hydrochloride, (+)-isomer; indeloxazine, (+)-isomer; Morpholine, 2-((1H-inden-7-yloxy)methyl)-

Networked: 27 relevant articles (6 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - indeloxazine: 27

Experts

1.	Aoki, Toshiaki: 4 articles (06/2015 - 03/2014)
2.	Matsuoka, Nobuya: 4 articles (06/2015 - 03/2014)
3.	Murai, Nobuhito: 4 articles (06/2015 - 03/2014)
4.	Tamura, Seiji: 4 articles (06/2015 - 03/2014)
5.	Tsukamoto, Mina: 2 articles (06/2014 - 03/2014)
6.	Hamakawa, Nozomu: 2 articles (04/2014 - 03/2014)
7.	Irie, Megumi: 1 article (06/2015)
8.	Nishigaki, Fusako: 1 article (06/2015)
9.	Takeshita, Nobuaki: 1 article (06/2015)
10.	Aoki, T: 1 article (03/2015)

Related Diseases

1.	Pain (Aches) 06/01/2015 - "AS1069562 also significantly improved the pain-related behavior of weight-bearing deficit in the chronic phase of the MIA model. " 07/01/1993 - "The shortened latency in these models was prolonged when indeloxazine was administered before training in doses which did not affect spontaneous movement or the response to pain in mature rats and administration of indeloxazine, immediately after training, also had an ameliorating effect on passive avoidance in the lesioned rats. " 06/01/2015 - "In the AIA model and the bradykinin-induced knee joint pain model, AS1069562 significantly ameliorated the pain-related behavior of weight-bearing deficit and the pain response, respectively. " 03/01/2014 - "Furthermore, AS1069562, duloxetine, and amitriptyline significantly improved spontaneous pain-associated behavior. " 03/19/2015 - "These results suggest that SERT occupancy level is useful in determining appropriate analgesic doses of AS1069562 and duloxetine for treating pain symptoms in FM patients. "
2.	Hyperalgesia 06/15/2014 - "In the PGF2α-induced allodynia model, AS1069562 and amitriptyline significantly ameliorated allodynia, whereas duloxetine did not. " 06/15/2014 - "In the PGE2-induced allodynia model, AS1069562 and duloxetine significantly suppressed allodynia, whereas amitriptyline did not. " 03/01/2014 - "AS1069562 and amitriptyline significantly ameliorated thermal hyperalgesia, and duloxetine tended to ameliorate it. " 03/01/2014 - "In CCI rats, AS1069562 and duloxetine significantly ameliorated mechanical allodynia, whereas amitriptyline did not. " 04/01/2014 - "AS1069562 and duloxetine by single daily administration for 4 weeks significantly improved mechanical allodynia in STZ-induced diabetic rats and did not affect plasma glucose level or body weight. "
3.	Brain Ischemia (Cerebral Ischemia) 11/01/1987 - "These findings indicate that indeloxazine possesses protective effects on cerebral ischemia presumably due, in part, to improvement of the cerebral energy metabolism." 11/01/1987 - "Protective effects of indeloxazine hydrochloride on cerebral ischemia in animals." 11/01/1991 - "Effects of indeloxazine hydrochloride on behavioral and biochemical changes in the chronic phase of focal cerebral ischemia in rats." 12/01/1989 - "Indeloxazine enhanced passive learned behaviour in rats and ameliorated cerebral ischemia-induced learned disturbances in gerbils. " 11/01/1987 - "Effects of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride, YM-08054] on cerebral ischemia were investigated in animals. "
4.	Hypoxia (Hypoxemia) 04/01/1987 - "Indeloxazine significantly prolonged survival time of mice subjected to anoxia and improved anoxia-induced impairment of the passive and active avoidance learnings in rats. " 12/01/1989 - "These results are in contrast to the findings that all tested cerebral metabolic enhancers, including indeloxazine, prolonged the survival time of mice subjected to anoxia. " 04/01/1987 - "Effects of indeloxazine hydrochloride (YM-08054) on anoxia." 04/01/1987 - "Effects of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride, YM-08054] on anoxia were examined. " 03/01/1989 - "Oral administration of both indeloxazine (10 mg/kg) and each of the cerebral vasodilators, such as nicardipine (10 mg/kg), cinepazide (100 mg/kg), ifenprodil (1 mg/kg), pentoxyfylline (1 mg/kg) and vinpocetine (10 mg/kg) significantly prolonged the survival time of mice subjected to anoxia, without affecting pentobarbital-induced sleeping time. "
5.	Amnesia (Dissociative Amnesia) 11/01/1987 - "Indeloxazine (2 mg/kg) significantly prolonged the latency of step-through in this amnesic model, indicating a reversal effect on the ischemia-induced amnesia. " 07/01/1987 - "Amnesia in scopolamine-treated rats, disturbances of consciousness in concussed mice and synchronized EEG in rabbits with lesions of the internal capsule were improved by the administration of indeloxazine. " 04/01/1989 - "Indeloxazine ameliorated cycloheximide-induced amnesia in mice, indicating a facilitatory effect of this drug on cerebral functions. "

Related Drugs and Biologics

1.	Duloxetine Hydrochloride (Cymbalta)
2.	Antidepressive Agents (Antidepressants)
3.	Amitriptyline (Elavil)
4.	Scopolamine (Hyoscine)
5.	Glucose (Dextrose)
6.	bifemelane
7.	idebenone
8.	propentofylline
9.	indeloxazine
10.	Serotonin (5 Hydroxytryptamine)

Related Therapies and Procedures

1.	Spinal Injections
2.	Analgesia
3.	Aftercare (After-Treatment)
4.	Oral Administration