paracymethadol

nor-LAAM refers to (S-(R*,R*))-(-)-isomer

Also Known As:

1 alpha-acetylnormethadol; 6-(methylamino)-4,4-diphenyl-3-heptanol acetate; N-desmethyl-1-alpha-acetylmethadol; NLAAM; l-alpha-noracetylmethadol; nor-LAAM; noracetylmethadol; paracymethadol hydrochloride; paracymethadol hydrochloride, (R*,R*)-(+-)-isomer; paracymethadol hydrochloride, (S-(R*,R*))-isomer; paracymethadol, (R*,R*)-(+-)-isomer; paracymethadol, (R-(R*,R*))-isomer; paracymethadol, (S-(R*,R*))-(-)-isomer; alpha-ethyl-beta- (2-(methylamino)propyl)-beta-phenylbenzeneethanol, acetate (ester)

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Methadone: 5474
    - Methadyl Acetate: 102
      - paracymethadol: 5

Experts

1.	Schrott, Lisa M: 2 articles (11/2004 - 10/2002)
2.	Sparber, Sheldon B: 2 articles (11/2004 - 10/2002)
3.	Chen, Xiao Liang: 1 article (01/2003)
4.	Kang, Jiesheng: 1 article (01/2003)
5.	Rampe, David: 1 article (01/2003)
6.	Wang, Hongge: 1 article (01/2003)
7.	Baumgart, Mary Irene: 1 article (10/2002)
8.	Zhang, Xuewei: 1 article (10/2002)

Related Diseases

1.	Opioid-Related Disorders (Opiate Addiction) 01/01/2003 - "We conclude that the proarrhythmic effects of l-alpha-acetylmethadol are due to specific blockade of the HERG cardiac K(+) channel and that its active metabolite noracetylmethadol may provide a safer alternative in the treatment of opiate addiction." 09/01/1995 - "This study evaluated levo-alpha-noracetylmethadol (NorLAAM), the first N-demethylated metabolite of levo-alpha-acetylmethadol (LAAM), a long-acting morphine-like (mu) agonist, approved in 1993 to treat opiate dependence. " 11/01/2004 - "We have established procedures to reliably induce opiate dependence in the chick embryo via in ovo injection, early in embryonic development, of the long-acting and potent opiate N-desmethyl-l-alpha-noracetylmethadol (NLAAM). " 10/01/2002 - "In ovo administration of the long-acting opiate N-desmethyl-l-alpha-noracetylmethadol (NLAAM) induces opiate dependence in the chick embryo. "
2.	Shock 08/01/1997 - "The discriminative stimulus effects of l-alpha-acetylmethadol (LAAM), l-alpha-acetylnormethadol (nor-LAAM), l-alpha-acetyldinormethadol (dinor-LAAM), buprenorphine and methadone were investigated in morphine-treated (3.2 mg/kg/day) rhesus monkeys (n = 3-6) discriminating between saline and naltrexone (0.01 mg/kg) and responding under a fixed ratio (FR) schedule of stimulus-shock termination. "

Related Drugs and Biologics

1.	Methadyl Acetate (LAAM)
2.	Morphine (MS Contin)
3.	paracymethadol
4.	Opiate Alkaloids
5.	Naltrexone (ReVia)
6.	Methadone (Dolophine)
7.	Buprenorphine (Subutex)
8.	1 alpha-acetyldinormethadol