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N- 3- methylbutyl- N- 1- methylacetonylnitrosamine
structure
Also Known As:
MAMBNA; N-1-methylacetonyl-N-3-methylbutyl-nitrosamine; 2-Butanone, 3-((3-methylbutyl)nitrosoamino)-
Networked:
4
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Nitroso Compounds: 446
Nitrosamines: 1539
N-3-methylbutyl-N-1-methylacetonylnitrosamine: 4
Related Diseases
1.
Neoplasms (Cancer)
07/01/1986 - "
This may indicate that the intragastric synthesis of MAMBNA is less effective in the production of forestomach tumors in mice.
"
07/01/1986 - "
However, the induction of such tumors by in vivo formation of MAMBNA required longer time and much larger doses.
"
09/01/1985 - "
In the present studies the carcinogenicity of MAMBNA is shown by the induction of forestomach carcinomas and liver tumors in mice and rats following the gastric intubation of this compound.
"
2.
Carcinoma (Carcinomatosis)
09/01/1985 - "
The earliest forestomach carcinoma appeared in a rat treated for 454 days, receiving 4480 mg of MAMBNA, and the other 10 carcinomas occurred in animals treated for 518-640 days.
"
09/01/1985 - "
In the present studies the carcinogenicity of MAMBNA is shown by the induction of forestomach carcinomas and liver tumors in mice and rats following the gastric intubation of this compound.
"
07/01/1986 - "
Forestomach papilloma and carcinoma, as well as liver lesion, were induced in mice by gavaging precursors of the new nitrosamine, MAMBNA (N-3-methylbutyl-N-1-methylacetonylnitrosamine) and NaNO2.
"
07/01/1986 - "
[Induction of papilloma and carcinoma in the forestomach of mice by in vivo formation of N-3-methylbutyl-N-1-methylacetonylnitrosamine (MAMBNA)].
"
09/01/1985 - "
[Forestomach carcinoma and hepatoma induced in mice and rats by N-3-methylbutyl-N-1-methylacetonylnitrosamine (MAMBNA)].
"
3.
Papilloma (Papillomatosis)
09/01/1985 - "
In the experiment with 29 Wistar strain rats, administration of MAMBNA (20-120 mg/week) resulted in 11 epithelial hyperplasias in the lower esophagus, 14 atypical hyperplasias and papillomas, and 11 squamous carcinomas in the forestomach.
"
07/01/1986 - "
Forestomach papilloma and carcinoma, as well as liver lesion, were induced in mice by gavaging precursors of the new nitrosamine, MAMBNA (N-3-methylbutyl-N-1-methylacetonylnitrosamine) and NaNO2.
"
09/01/1985 - "
Among 42 mice of Kunming (KM) stock treated with MAMBNA (10-20 mg/week), 22 showed epithelial hyperplasia of the esophagus, 29 papillomas and 4 squamous carcinomas in the forestomach, and there were 6 liver adenomas and 3 hepatomas.
"
07/01/1986 - "
[Induction of papilloma and carcinoma in the forestomach of mice by in vivo formation of N-3-methylbutyl-N-1-methylacetonylnitrosamine (MAMBNA)].
"
4.
Esophageal Neoplasms (Esophageal Cancer)
07/01/1982 - "
A new nitrosamine compound, N-1-methylacetonyl-N-3-methylbutyl-nitrosamine (MAMB-NA), isolated from corn bread inoculated with moulds commonly occurring in Linxian County, a high incidence area for esophageal cancer in North China was tested for its potential carcinogenicity in vitro.
"
11/01/1986 - "
This report, for the first time, demonstrates that diethyl-nitrosamine (NDEA) and a new nitrosamine compound-N-1-methylacetonyl-N-3-methylbutyl-nitrosamine (MAMBNA), which are suspicious carcinogens of esophageal cancer (EC) in Linxian, Henan Province, are able to cause the malignant transformation (altered morphology, extended life span, anchorage independent growth, invasiveness, tumorigenicity, etc.) of normal diploid fibroblasts derived from human fetal lung.
"
5.
Hyperplasia
09/01/1985 - "
In the experiment with 29 Wistar strain rats, administration of MAMBNA (20-120 mg/week) resulted in 11 epithelial hyperplasias in the lower esophagus, 14 atypical hyperplasias and papillomas, and 11 squamous carcinomas in the forestomach.
"
09/01/1985 - "
Among 42 mice of Kunming (KM) stock treated with MAMBNA (10-20 mg/week), 22 showed epithelial hyperplasia of the esophagus, 29 papillomas and 4 squamous carcinomas in the forestomach, and there were 6 liver adenomas and 3 hepatomas.
"
Related Drugs and Biologics
1.
N- 3- methylbutyl- N- 1- methylacetonylnitrosamine
2.
Nitrosamines
3.
Carcinogens