|1.||Natsume, Atsushi: 4 articles (10/2013 - 07/2006)|
|2.||Wakabayashi, Toshihiko: 4 articles (10/2013 - 07/2006)|
|3.||Kajita, Y: 4 articles (03/2001 - 01/2000)|
|4.||Yoshida, J: 4 articles (03/2001 - 01/2000)|
|5.||Wakabayashi, T: 4 articles (03/2001 - 01/2000)|
|6.||Fujii, Masazumi: 3 articles (10/2013 - 07/2007)|
|7.||Yoshida, Jun: 3 articles (07/2007 - 09/2005)|
|8.||Yamamoto, Masaaki: 3 articles (11/2005 - 07/2002)|
|9.||Fukushima, Takeo: 3 articles (11/2005 - 07/2002)|
|10.||Tsugu, Hitoshi: 3 articles (11/2005 - 07/2002)|
05/01/1992 - "[Study on the therapy of multiple myelomas--initial induction therapy (MP, IFN alpha, steroid pulse) and maintenance therapy (VMP, MP continuous, VEP, MCNU)]."
03/01/1985 - "MCNU was less effective in malignant lymphoma (ML) and multiple myeloma (MM) than in myeloproliferative disorders. "
06/01/2000 - "This pilot study evaluated the efficacy of a new combination chemotherapy with a newly developed nitrosourea derivative ranimustine and evaluated the efficacy of interferon alpha (IFN-alpha) maintenance in previously untreated patients with multiple myeloma (MM). "
01/01/2003 - "Combination chemotherapy of ranimustine, doxorubicine, and dexamethasone for relapsing multiple myeloma--a pilot study."
04/01/1990 - "[Combination chemotherapy of MCNU and interferon alfa-2a (genetical recombination) for advanced multiple myeloma]."
01/01/1994 - "These findings suggest that ventriculolumbar perfusion of MCNU may be effective in the treatment of subarachnoid dissemination of malignant glioma notwithstanding some local histological changes."
11/01/1995 - "[Intratumoral pharmacokinetics following intraarterial administration of MCNU in patients with malignant gliomas]."
05/01/1995 - "[Effect of intra-arterial and local administration of MCNU on cerebral malignant gliomas]."
01/01/1994 - "Ventriculolumbar perfusion of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU), a water soluble nitrosourea with log P -0.71, may be efficacious in the treatment of subarachnoid dissemination of malignant glioma. "
06/01/1993 - "Therefore, since the antitumor activity of MCNU against malignant glioma seems to require a certain time depending on the case, it is recommended that MCNU be given as maintenance therapy for at least half a year."
11/01/1991 - "These results clearly suggest that MCNU is worthy of clinical study to examine the antitumor activity against various solid tumors."
07/01/1998 - "We investigated the effects of MCNU (methyl-6)3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy- alpha-D-glucopyranoside), a nitrosourea anti-tumor agent developed in Japan, on cell growth and differentiation in five human myeloma cell lines and compared it with relative expression levels of MDR-1 gene. "
07/01/1998 - "Effect of the nitrosourea anti-tumor chemotherapeutical agent MCNU on five human myeloma cell lines."
11/01/1995 - "These results suggests that MCNU may transfer into the tumor tissues. "
05/01/1995 - "Local administration of MCNU was performed by puncture of the Ommaya reservoir placed within the cavity after tumor resection. "
|4.||Astrocytoma (Pilocytic Astrocytoma)
11/01/1995 - "This clinical study was undertaken to examine intratumoral (i.t.) pharmacokinetics after intraarterial (i.a.) administration of MCNU (80mg/m2) in 5 patients with glioblastoma (GB) and 2 with anaplastic astrocytoma (AA). "
05/01/1995 - "Twenty-six patients with cerebral malignant glioma (7 cases of astrocytoma Grade 3, and 19 of astrocytoma Grade 4) were treated by intra-arterial and local administration of MCNU. "
11/01/1995 - "Although a longer and more careful clinical observation is required, the authors conclude that chemotherapy with MCNU and/or ACNU may benefit patients with unresectable pilocytic astrocytoma requiring treatment. "
09/01/1995 - "[The efficacy of granisetron as a prophylactic anti-emetic agent used in conjunction with MCNU and VP16 chemotherapeutic regimens in the management of a pediatric case of hypothalamic anaplastic astrocytoma]."
11/01/2003 - "Recombinant mutant human tumor necrosis factor-alpha (TNF-SAM2) immunotherapy with ranimustine chemotherapy and concurrent radiation therapy for malignant astrocytomas."
|5.||Brain Neoplasms (Brain Tumor)
12/01/1984 - "These results suggest that MCNU therapy is effective for patients with malignant brain tumors."
07/01/1985 - "A total of 71 cases with primary brain tumors (44 cases) and metastatic brain tumors (30 cases) were entered into our clinical studies with MCNU and radiation therapy or MCNU alone. "
01/01/1993 - "We observed the tissue delivery of a novel water-soluble nitrosourea, 1-(2-chloroethyl)-3-(methyl-alpha-D-glucopyranos-6-yl)-1-nitros our ea (MCNU) in rats bearing experimental brain tumors by conducting autoradiography on all. "
02/01/1987 - "Twenty-five patients with primary or metastatic brain tumor were treated with two administrations of MCNU, 67-125 mg/m2 i.v., at 1-293 day intervals. "
07/01/1985 - "[Clinical trial of MCNU for malignant brain tumors]."
|3.||Etoposide (VP 16)
|1.||Drug Therapy (Chemotherapy)
|2.||Combination Drug Therapy (Combination Chemotherapy)
|4.||Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)