ranimustine

RN given refers to (alpha)-(D)-isomer; structure

Also Known As:

MCNU; methyl 6-((((2-chloroethyl)nitrosoamino)carbonyl) amino)-6-deoxy-alpha-D-glucopyranoside; methyl 6-(3-(2-chloroethyl)-3-nitrosoiureido)-6-deoxy-alpha-D-glucopyranoside; methyl 6-(3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy-alpha-D-glucopyranoside; ranimustine, (beta)-(D)-isomer; alpha-D-Glucopyranoside, methyl 6-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-6-deoxy-

Networked: 149 relevant articles (32 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Nitrosourea Compounds: 21
      - ranimustine: 149
- Nitroso Compounds: 446
  - Nitrosourea Compounds: 21
    - ranimustine: 149

Experts

1.	Tsukasaki, Kunihiro: 5 articles (12/2020 - 12/2007)
2.	Utsunomiya, Atae: 4 articles (12/2020 - 02/2004)
3.	Natsume, Atsushi: 4 articles (10/2013 - 07/2006)
4.	Wakabayashi, Toshihiko: 4 articles (10/2013 - 07/2006)
5.	Kajita, Y: 4 articles (03/2001 - 01/2000)
6.	Wakabayashi, T: 4 articles (03/2001 - 01/2000)
7.	Yoshida, J: 4 articles (03/2001 - 01/2000)
8.	Ishizawa, Kenichi: 3 articles (12/2020 - 11/2012)
9.	Fujii, Masazumi: 3 articles (10/2013 - 07/2007)
10.	Yoshida, Jun: 3 articles (07/2007 - 09/2005)

Related Diseases

1.	Multiple Myeloma 03/01/1985 - "MCNU was less effective in malignant lymphoma (ML) and multiple myeloma (MM) than in myeloproliferative disorders. " 06/01/2000 - "This pilot study evaluated the efficacy of a new combination chemotherapy with a newly developed nitrosourea derivative ranimustine and evaluated the efficacy of interferon alpha (IFN-alpha) maintenance in previously untreated patients with multiple myeloma (MM). " 05/01/1992 - "[Study on the therapy of multiple myelomas--initial induction therapy (MP, IFN alpha, steroid pulse) and maintenance therapy (VMP, MP continuous, VEP, MCNU)]." 01/01/2003 - "Combination chemotherapy of ranimustine, doxorubicine, and dexamethasone for relapsing multiple myeloma--a pilot study." 04/01/1990 - "[Combination chemotherapy of MCNU and interferon alfa-2a (genetical recombination) for advanced multiple myeloma]."
2.	Glioma (Gliomas) 01/01/1994 - "These findings suggest that ventriculolumbar perfusion of MCNU may be effective in the treatment of subarachnoid dissemination of malignant glioma notwithstanding some local histological changes." 11/01/1995 - "[Intratumoral pharmacokinetics following intraarterial administration of MCNU in patients with malignant gliomas]." 05/01/1995 - "[Effect of intra-arterial and local administration of MCNU on cerebral malignant gliomas]." 01/01/1994 - "Ventriculolumbar perfusion of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU), a water soluble nitrosourea with log P -0.71, may be efficacious in the treatment of subarachnoid dissemination of malignant glioma. " 01/01/1993 - "Delivery of a novel nitrosourea, MCNU, to the brain tissue in glioma-bearing rats. "
3.	Brain Neoplasms (Brain Tumor) 01/01/1993 - "We observed the tissue delivery of a novel water-soluble nitrosourea, 1-(2-chloroethyl)-3-(methyl-alpha-D-glucopyranos-6-yl)-1-nitros our ea (MCNU) in rats bearing experimental brain tumors by conducting autoradiography on all. " 02/01/1990 - "Brain metastases seemed to be slightly more frequent sensitive against MCNU than primary brain tumors. " 02/01/1987 - "Twenty-five patients with primary or metastatic brain tumor were treated with two administrations of MCNU, 67-125 mg/m2 i.v., at 1-293 day intervals. " 07/01/1985 - "[Clinical trial of MCNU for malignant brain tumors]." 12/01/1984 - "Part II: Clinical experience with MCNU on malignant brain tumors]."
4.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/01/1988 - "A new water-soluble nitrosourea derivative, methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU), was found to be useful for the treatment of chronic myelogenous leukemia (CML) in the chronic phase. " 12/01/1984 - "[Prolonged remission in a patient with chronic myelocytic leukemia (CML) by methyl 6-[3-(2-chloroethyl)-3-deoxy-alpha-D-glucopyranoside (MCNU)]." 05/01/1985 - "MCNU therefore seems a very effective drug for chronic myelogenous leukemia." 11/01/1989 - "[Chemotherapy of chronic myelogenous leukemia--VP(M) regimen initiated during its chronic phase, and evaluation of MCNU in the phase of blastic crisis]." 09/01/1987 - "[Prolonged disappearance of the Ph1 chromosome in a case of chronic myelogenous leukemia after administration of MCNU]."
5.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 11/01/2014 - "Safety and efficacy of high-dose cyclophosphamide, etoposide and ranimustine regimen followed by autologous peripheral blood stem cell transplant for patients with diffuse large B-cell lymphoma." 11/01/2018 - "Safety and efficacy of high-dose ranimustine (MCNU) containing regimen followed by autologous stem cell transplantation for diffuse large B-cell lymphoma." 07/01/2011 - "Safety and efficacy of high-dose ranimustine, cytarabine, etoposide and CY (MCVAC) regimen followed by autologous peripheral blood stem cell transplantation for high-risk diffuse large B-cell lymphoma." 11/01/2014 - "We retrospectively evaluated the safety and efficacy of high-dose chemotherapy consisting of cyclophosphamide, etoposide and ranimustine (CEM) with autologous peripheral blood stem cell transplant (PBSCT) in 55 adult patients with relapsed or high-risk de novo diffuse large B-cell lymphoma (DLBCL) or DLBCL associated with follicular lymphoma. " 10/01/2011 - "Ranimustine, ifosfamide, procarbazine, dexamethasone, and etoposide therapy for central nervous system recurrence of diffuse large B-cell lymphoma in patients with poor performance status: a pilot study."

Related Drugs and Biologics

1.	ranimustine
2.	Vincristine (Oncovin)
3.	Etoposide (VP 16)
4.	Cyclophosphamide (Cytoxan)
5.	Interferon-beta
6.	Procarbazine (Matulane)
7.	Melphalan (Alkeran)
8.	Prednisolone (Predate)
9.	Nimustine
10.	Carboplatin (JM8)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Radiotherapy
5.	MP regimen