|1.||Willison, Hugh J: 3 articles (11/2005 - 11/2003)|
|2.||Plomp, Jaap J: 3 articles (11/2005 - 11/2003)|
|3.||O'Hanlon, Graham M: 3 articles (11/2005 - 11/2003)|
|4.||Humphreys, Peter D: 3 articles (11/2005 - 11/2003)|
|5.||Halstead, Susan K: 3 articles (11/2005 - 11/2003)|
|6.||Goodfellow, John A: 1 article (11/2005)|
|7.||Morrison, Ian: 1 article (11/2005)|
|8.||Todd, Andrew J: 1 article (09/2004)|
|9.||Morgan, Bryan P: 1 article (09/2004)|
|10.||Morrison, Deborah B: 1 article (09/2004)|
10/24/1994 - "alpha-Latrotoxin causes massive release of norepinephrine from clonal rat pheochromocytoma PC12 cells, in the absence of external Ca2+, by an unknown mechanism. "
01/14/1986 - "alpha Latrotoxin, a presynaptically acting polypeptide neurotoxin, induces massive neurotransmitter release from both synapses of vertebrates and the neurosecretory cells of the line PC12, derived from a rat pheochromocytoma. "
06/15/1984 - "alpha Latrotoxin of black widow spider is known to bind with high affinity to surface sites of rat pheochromocytoma (PC12) cells, thereby causing depolarization, calcium influx and massive neurotransmitter release. "
02/01/1994 - "Alpha-latrotoxin channels in neuroblastoma cells."
06/01/1989 - "Human neuroblastoma cells acquire regulated secretory properties and different sensitivity to Ca2+ and alpha-latrotoxin after exposure to differentiating agents."
02/01/1994 - "The changes in ionic permeability induced by the application of alpha-latrotoxin to NG108-15 neuroblastoma x glioma cells were examined using the nystatin perforated-patch technique for whole-cell recording. "
06/01/1988 - "Intracellular calcium homeostasis in a human neuroblastoma cell line: modulation by depolarization, cholinergic receptors, and alpha-latrotoxin."
|3.||Miller Fisher Syndrome (Fisher Syndrome)
06/01/2003 - "Many patients with variant forms of Guillain-Barré syndrome (vGBS) associated with anti-ganglioside antibodies, including Miller Fisher syndrome (MFS), sometimes exhibit miniature endplate potential (MEPP) frequency increases (MFI, described as alpha-latrotoxin-like effects in a previous report) and the factor to produce this effect is present in their sera. "
11/01/2003 - "Miller Fisher syndrome-associated anti-GQ1b ganglioside antibodies produce an acute complement-dependent neuroexocytic effect at the mouse neuromuscular junction (NMJ) that closely resembles the effect of alpha-latrotoxin (LTx). "
09/01/2004 - "In a model system in mice, one mechanism by which anti-disialoside Abs have been demonstrated to induce paralysis is through a complement dependent blocking effect on transmitter release at the neuromuscular junction, similar to the effects of alpha-latrotoxin. "
11/15/2005 - "We have shown previously that at murine NMJs, anti-disialosyl antibodies induce an alpha-latrotoxin-like effect, electrophysiologically characterized by transient massive increase of spontaneous neurotransmitter release followed by block of evoked release, resulting in paralysis of the muscle preparation. "
03/01/2000 - "alpha-Latrotoxin interaction with a fusion construct composed of the extracellular domain of CIRL-1 anchored to the membrane by the transmembrane domain of vesicular stomatitis virus glycoprotein, and with neurexin 1alpha, an alpha-latrotoxin receptor structurally unrelated to CIRL-1, produced channels virtually identical with those observed with wild-type CIRL-1. "
|1.||Neurotransmitter Agents (Neurotransmitter)
|4.||Complement System Proteins (Complement)
|10.||black widow spider venom