HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

3-hydroxyisobutyric acid

RN given refers to cpd without isomeric designation

Also Known As:

3-hydroxyisobutyric acid, (R)-isomer; 3-hydroxy-2-methylpropanoic acid

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Hydroxy Acids: 94
    - Hydroxybutyrates: 6
      - 3-hydroxyisobutyric acid: 10
  - Acyclic Acids
    - Butyrates: 2613
      - Hydroxybutyrates: 6
        3-hydroxyisobutyric acid: 10
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Butyrates: 2613
      - Hydroxybutyrates: 6
        3-hydroxyisobutyric acid: 10

Experts

1.	Sass, Jörn Oliver: 2 articles (01/2022 - 05/2012)
2.	Al-Hertani, Walla: 1 article (01/2022)
3.	Donati, Maria A: 1 article (01/2022)
4.	Ferdinandusse, Sacha: 1 article (01/2022)
5.	Fung, Ernest: 1 article (01/2022)
6.	Koster, Janet: 1 article (01/2022)
7.	Marquardt, Thorsten: 1 article (01/2022)
8.	Pasquini, Elisabetta: 1 article (01/2022)
9.	Reeves, Melanie: 1 article (01/2022)
10.	Rombough, Catherine: 1 article (01/2022)

Related Diseases

1.	3-Hydroxyisobutyric aciduria 05/01/2012 - "Mutation analysis in the ALDH6A1 gene can reveal a cause of 3-hydroxyisobutyric aciduria, which may present with only slightly increased urinary levels of 3-hydroxyisobutyric acid, if a patient is metabolically stable." 05/01/2008 - "Considering the importance of the affected enzyme activities for brain metabolism homeostasis and neurotransmision, it is suggested that increased tissue levels of 3-hydroxyisobutyric acid may contribute to the neurodegeneration of patients affected by 3-hydroxyisobutyric aciduria and possibly explain previous reports describing elevated production and excretion of lactate." 01/01/2022 - "A deficiency of 3-hydroxyisobutyric acid dehydrogenase (HIBADH) has been recently identified as a cause of primary 3-hydroxyisobutyric aciduria in two siblings; the only previously recognized primary cause had been a deficiency of methylmalonic semialdehyde dehydrogenase, the enzyme that is immediately downstream of HIBADH in the valine catabolic pathway and is encoded by the ALDH6A1 gene. " 02/25/2000 - "The chiral metabolites 3-hydroxyisobutyric acid (HIBA) and 3-aminoisobutyric acid (AIBA) are intermediates in the pathways of L-valine and thymine and play an important role in the diagnosis of the very rare inherited metabolic diseases 3-hydroxyisobutyric aciduria (McKusick 236975) and methylmalonic semialdehyde dehydrogenase deficiency (McKusick 603178-MSDD). "
2.	Ketosis 10/15/1975 - "Accumulation of 3-hydroxyisobutyric acid, 2-methyl-3-hydroxybutyric acid and 3-hydroxyisovaleric acid in ketoacidosis." 01/01/2017 - "Besides the elevated excretion of 3-OH-butyrate, adipic acid, which are typical marks of ketosis, other metabolites such as 3-aminoisobutyric acid, 3-hydroxyisobutyric acid, 3-hydroxypropionic acid and 2-ethyl-3-hydroxypropionic acids were observed in increased amounts in the urine. "
3.	Insulin Resistance 11/14/2023 - "3-Hydroxyisobutyric acid (3-HIB) is a muscle-derived metabolite reflecting systemic insulin resistance. " 01/01/2018 - "Branched-chain amino acids (BCAAs) metabolite, 3-Hydroxyisobutyric acid (3-HIB) has been identified as a secreted mediator of endothelial cell fatty acid transport and insulin resistance (IR) using animal models. "
4.	Prostatic Neoplasms (Prostate Cancer) 09/10/2018 - "3-hydroxyisobutyric acid significantly decreased between two groups of prostate cancer patients: ≥7 Gleason patients and <7 Gleason patients. "
5.	Metabolic Diseases (Metabolic Disease) 02/25/2000 - "The chiral metabolites 3-hydroxyisobutyric acid (HIBA) and 3-aminoisobutyric acid (AIBA) are intermediates in the pathways of L-valine and thymine and play an important role in the diagnosis of the very rare inherited metabolic diseases 3-hydroxyisobutyric aciduria (McKusick 236975) and methylmalonic semialdehyde dehydrogenase deficiency (McKusick 603178-MSDD). "

Related Drugs and Biologics

1.	Valine (L-Valine)
2.	Oxidoreductases (Dehydrogenase)
3.	Enzymes
4.	3-aminoisobutyric acid
5.	Lactic Acid (Lactate)
6.	Thymine
7.	Fatty Acids (Saturated Fatty Acids)
8.	Branched-Chain Amino Acids
9.	Acids
10.	hydracrylic acid