|1.||Liu, Jihong: 3 articles (01/2010 - 04/2003)|
|2.||Ye, Zhangqun: 3 articles (01/2010 - 04/2003)|
|3.||Hosen, Mohammad J: 2 articles (04/2015 - 09/2014)|
|4.||Vanakker, Olivier M: 2 articles (04/2015 - 09/2014)|
|5.||Guo, Xiaolin: 2 articles (01/2010 - 10/2009)|
|6.||Yang, Jun: 2 articles (01/2010 - 10/2009)|
|7.||Wang, Tao: 2 articles (01/2010 - 10/2009)|
|8.||Qiao, Jiankun: 2 articles (01/2010 - 10/2009)|
|9.||Wang, Shaogang: 2 articles (10/2009 - 04/2003)|
|10.||Mutucumarana, V P: 2 articles (04/2004 - 10/2000)|
|1.||Hepatocellular Carcinoma (Hepatoma)
01/01/1990 - "The present study indicates that in hepatocellular carcinoma an increase in prothrombin precursor concentration does not induce vitamin-K-dependent carboxylase activity, which is ordinarily observed in normal liver; probably an overproduction of prothrombin precursor with reduced gamma-carboxylation causes an increase in plasma des-gamma-carboxyprothrombin in patients with hepatocellular carcinoma."
10/01/2008 - "Exon 2 deletion splice variant of gamma-glutamyl carboxylase causes des-gamma-carboxy prothrombin production in hepatocellular carcinoma cell lines."
09/01/1995 - "A characteristic defect occurs in rat and human hepatocellular carcinoma (HCC) resulting in a loss of function of the vitamin K-dependent enzyme gamma-glutamyl-carboxylase in the tumor but not in the underlying liver. "
01/01/1995 - "To clarify the mechanism of production of des-gamma-carboxy (abnormal) prothrombin (DCP) by hepatocellular carcinoma (HCC), we measured the levels of vitamin K, DCP, immunoreactive prothrombin and the activity of gamma-glutamyl carboxylase in liver tissues from HCC patients and in the medium of cultured human hepatoma cells. "
06/01/1993 - "This cell line has a decreased activity of the microsomal vitamin K-dependent carboxylase when compared to a control (H4IIEC3) hepatoma line, does not increase intracellular prothrombin concentrations in response to vitamin K depletion, and secretes undercarboxylated prothrombin even when grown in vitamin K supplemented media. "
01/01/1998 - "Enhanced renal vitamin-K-dependent gamma-glutamyl carboxylase activity in experimental rat urolithiasis."
04/01/2003 - "To study the activity of vitamin K-dependent gamma-glutamyl carboxylase in patients with calcium oxalate (CaOx) urolithiasis compared with healthy individuals and to assess its relationship to the renal calcium oxalate urolithiasis. "
01/01/2010 - "To evaluate the correlation between vitamin K-dependent gamma-glutamyl carboxylase (GGCX) and the formation of calcium oxalate urolithiasis (COU). "
01/01/2010 - "Activity and expression of vitamin K-dependent gamma-glutamyl carboxylase in patients with calcium oxalate urolithiasis."
10/01/2009 - "Genetic mutation of vitamin K-dependent gamma-glutamyl carboxylase domain in patients with calcium oxalate urolithiasis."
06/15/2007 - "Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase."
09/01/2006 - "Defective gamma-glutamyl carboxylase activity and bleeding in Rambouillet sheep."
04/01/2004 - "A mutation (W501S) in the vitamin K-dependent gamma-glutamyl carboxylase (VKC) that leads to a congenital bleeding disorder was recently discovered in two patients. "
01/01/2014 - "Liver-specific γ-glutamyl carboxylase-deficient mice display bleeding diathesis and short life span."
10/20/2000 - "Patients with mutation L394R in gamma-glutamyl carboxylase have a severe bleeding disorder because of decreased biological activities of all vitamin K-dependent coagulation proteins. "
|3.||vitamin K epoxidase (vitamin K epoxide reductase)
|5.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|7.||Proteins (Proteins, Gene)
|8.||Blood Coagulation Factors (Coagulation Factor)
|9.||Messenger RNA (mRNA)
|10.||Prothrombin (Factor II)