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glutamin-(asparagin-)ase
catalyzes hydrolysis of both glutamine & asparagine with a ratio of glutaminase to asparaginase of 1.45:1.0
Also Known As:
L-glutaminase-L-asparaginase
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Amidohydrolases: 43
glutamin-(asparagin-)ase: 6
Experts
1.
Aleksandrova, S S
: 1 article (11/2000)
2.
Sokolov, N N
: 1 article (11/2000)
3.
Zanin, V A
: 1 article (11/2000)
Related Diseases
1.
Neoplasms (Cancer)
06/01/1979 - "
Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic L-glutaminase-L-asparaginase.
"
11/01/2000 - "
[Bacterial L-asparaginase and glutamin(asparagin)ase: some properties, structure and anti-tumor activity].
"
09/01/1983 - "
The effect of glutamin (asparagin)ase from Pseudomonas fluorescens and Pseudomonas boreopolis 526 on DNA synthesis by tumor cells, lines CaOv and L8, has been studied.
"
09/01/1983 - "
[Effect of glutamin(asparagin)ase preparations from microorganisms on DNA synthesis in tumor cells].
"
06/01/1979 - "
Treatment with Acinetobacter L-glutaminase-L-asparaginase decreased the L-asparagine and L-glutamine levels in acid extracts of the Ehrlich tumor.
"
2.
Leukemia
06/01/1979 - "
Achromobacter L-glutaminase-L-asparaginase: human pharmacology, toxicology, and activity in acute leukemias.
"
3.
Carcinoma (Carcinomatosis)
01/01/1984 - "
Glutamin (asparagin)ase from Pseudomonas boreopolis 526 is shown to produce a cytotoxic effect on the human ovary carcinoma cells (CaOv line), Fisher lympholeukemia (L-8 line) and Burkitt's lymphoma cells (P3HR line).
"
4.
Burkitt Lymphoma (Burkitt's Lymphoma)
01/01/1984 - "
Glutamin (asparagin)ase from Pseudomonas boreopolis 526 is shown to produce a cytotoxic effect on the human ovary carcinoma cells (CaOv line), Fisher lympholeukemia (L-8 line) and Burkitt's lymphoma cells (P3HR line).
"
Related Drugs and Biologics
1.
Glutamine (L-Glutamine)
2.
DNA (Deoxyribonucleic Acid)
3.
Asparagine
4.
Asparaginase (Elspar)
5.
Acids