|1.||Keller, Kirstie E: 2 articles (03/2014 - 11/2012)|
|2.||Lee, Young-Sam: 2 articles (03/2014 - 11/2012)|
|3.||Dwyer, Zachary W: 1 article (03/2014)|
|4.||Doctor, Zainab M: 1 article (03/2014)|
|5.||Tan, Irene S: 1 article (11/2012)|
|6.||Desguerre, Isabelle: 1 article (01/2009)|
|7.||Ceballos-Picot, Irène: 1 article (01/2009)|
|8.||Verrieres, Séverine: 1 article (01/2009)|
|9.||Vincent, Marie Françoise: 1 article (01/2009)|
|10.||Rio, Marlène: 1 article (01/2009)|
03/06/2014 - "SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells."
11/23/2012 - "Upon glucose starvation, cellular SAICAR concentration increased in an oscillatory manner and stimulated PKM2 activity in cancer cells. "
05/01/2014 - "SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation."
11/23/2012 - "Changes in SAICAR amounts in cancer cells altered cellular energy level, glucose uptake, and lactate production. "
11/23/2012 - "SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions."
|2.||Mental Retardation (Idiocy)
01/01/2009 - "Patients with adenylosuccinate lyase deficiency show a variable combination of mental retardation, epilepsy and autistic features and are usually discovered during screens for unexplained encephalopathy using the Bratton-Marshall assay that reveals the excretion of the succinylaminoimidazolecarboxamide riboside (SAICAr). "
01/01/1993 - "Two main subtypes of the defect are type I with severe mental retardation and succinyladenosine/succinyl-AICAriboside ratios around 1, and type II with slight mental delay and succinyladenosine/succinyl-AICAriboside ratios around 4. We report that in fibroblasts of type I patients, the activity of ASase with both adenylosuccinate and succinyl-AICAR is about 30% of normal. "
|4.||Inborn Errors Metabolism (Inborn Errors of Metabolism)
|5.||Metabolic Diseases (Metabolic Disease)
|1.||Protein Kinases (Protein Kinase)
|5.||3-Deazauridine (3 Deazauridine)
|8.||Inosine Monophosphate (IMP)