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ethanolamine O-sulfate
Also Known As:
2-aminoethyl hydrogen sulfate; 2-aminoethanol, hydrogen sulfate (ester)
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Ethanolamines: 16
ethanolamine O-sulfate: 7
Alcohols: 595
Ethanol: 23169
Ethanolamines: 16
ethanolamine O-sulfate: 7
Amino Alcohols: 20
Ethanolamines: 16
ethanolamine O-sulfate: 7
Related Diseases
1.
Anorexia
01/01/1989 - "
Effects of lateral hypothalamic lesions on the anorexia induced by ethanolamine-O-sulfate.
"
01/01/1989 - "
Intracisternal (IC) injection of the GABA-transaminase inhibitor, ethanolamine-O-sulfate (EOS), has been previously shown to induce dose-dependent anorexia in normal rats as well as to reverse overeating in several rodent models of acute and chronic hyperphagia.
"
01/01/1984 - "
To determine the generality of these findings we tested the ability of the GABA-T inhibitor ethanolamine-O-sulfate (EOS), to produce anorexia in three animal models of obesity: rats with medial hypothalamic lesions, rats exposed to palatable foods or Zucker fatty rats.
"
06/01/1992 - "
To explore recent suggestions that genetically obese Zucker rats show less anorexia when brain gamma-aminobutyric acid (GABA) is elevated, obese vs. lean littermates received 100, 50 and 0 micrograms of the GABA-transaminase inhibitor, ethanolamine-O-sulfate (EOS), intra-cisternally in a longitudinal design where their feeding patterns were monitored 24 h daily.
"
2.
Seizures (Absence Seizure)
09/01/1983 - "
Three other GABA transaminase inhibitors, gamma-vinyl GABA (450 and 900 mg/kg i.p.), gamma-acetylenic GABA (50-150 mg/kg i.p.) and ethanolamine-O-sulfate (250-750 mg/kg i.p.), were inactive against ethanol withdrawal audiogenic seizures and forelimb tremors.
"
04/01/1985 - "
A variety of drugs that specifically manipulate inhibitory or excitatory neurotransmitter systems proved capable of dose dependently blocking these seizures, i.e., the anticholinergic drug biperiden (ED50 12 mg/kg i.p.), the excitatory amino acid antagonist (+/-)-2-amino-7-phosphonoheptanoic acid (120 mg/kg), the gamma-aminobutyric acid (GABA) agonists muscimol (0.66 mg/kg), 4,5,6,7-tetrahydroisoxazolo(5,4-c) pyridine-3-ol (1.3 mg/kg), progabide (50 mg/kg) and its acidic metabolite SL 75102 (45 mg/kg), the GABA aminotransferase inhibitors aminooxyacetic acid (0.9 mg/kg), gamma-acetylenic GABA (2.1 mg/kg) and ethanolamine-O-sulfate (1000 mg/kg), the GABA uptake inhibitor (-)-nipecotic acid ethyl ester (21 mg/kg), the dopamine agonist apomorphine (approximately 5 mg/kg), the dopamine precursor 3,4-dihydroxy-L-phenylalanine (34 mg/kg), and the alpha-adrenoceptor agonists clonidine (0.38 mg/kg) and xylazine (approximately 10 mg/kg).
"
3.
Tremor (Tremors)
09/01/1983 - "
Three other GABA transaminase inhibitors, gamma-vinyl GABA (450 and 900 mg/kg i.p.), gamma-acetylenic GABA (50-150 mg/kg i.p.) and ethanolamine-O-sulfate (250-750 mg/kg i.p.), were inactive against ethanol withdrawal audiogenic seizures and forelimb tremors.
"
4.
Pain (Aches)
12/01/1988 - "
To this end, various doses of the GABA-T inhibitors ethanolamine-o-sulfate (EOS) and gamma-vinyl GABA (GVG) were injected intracisternally and effects on whole brain GABA, food and water intake, open field activity, catalepsy indices, pain sensitivity, and core temperature were assessed 24 h later.
"
5.
Obesity
01/01/1984 - "
To determine the generality of these findings we tested the ability of the GABA-T inhibitor ethanolamine-O-sulfate (EOS), to produce anorexia in three animal models of obesity: rats with medial hypothalamic lesions, rats exposed to palatable foods or Zucker fatty rats.
"
Related Drugs and Biologics
1.
gamma-Aminobutyric Acid (GABA)
2.
4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)
3.
Vigabatrin
4.
4-amino-5-hexynoic acid
5.
GABA Uptake Inhibitors
6.
GABA Agonists (GABA Receptor Agonists)
7.
Excitatory Amino Acid Antagonists
8.
Cholinergic Antagonists (Anticholinergics)
9.
Dopamine Agonists (Dopamine Agonist)
10.
Neurotransmitter Agents (Neurotransmitter)
Related Therapies and Procedures
1.
Injections
2.
Cannula