meclonazepam

Also Known As:

(+)-(S)-5-(o-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-2H-1,4-benzodiazepin-2-one; (R)-meclonazepam; 2H-1,4-benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-, (R)-; 2H-1,4-benzodiazepin-2-one, 5-(2-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro-, (S)-; 3-methylclonazepam; 5-(2-chlorophenyl)-1,3-dihydro-3-methyl-7-nitro- 2H-1,4-benzodiazepin-2-one; RO 11-3128; RO 11-3128 002; RO 11-3128-002; RO 11-3624; RO 11-3624-001; RO-11-3128; RO-11-3624; RO11-3128; RO11-3624; meclonazepam, (R)-isomer; meclonazepam, (S)-isomer; meclonazepamum

Networked: 8 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Benzodiazepinones
        Clonazepam: 1396
        meclonazepam: 8

Experts

1.	Cioli, D: 1 article (01/2008)
2.	Pica-Mattoccia, L: 1 article (01/2008)
3.	Ruppel, A: 1 article (01/2008)
4.	Xia, C M: 1 article (01/2008)

Related Diseases

1.	Infections 07/01/1994 - "Thus, quantitative and qualitative changes to antigen presentation by Ro11-3128 treatment early after infection may underlie the immunoprotective efficacy of Ro11-3128-abbreviated infections." 11/01/1990 - "As with 20 krad-irradiated infections in mice, the present study shows that the immunity induced by Ro11-3128 termination of unattenuated infections at the skin stage is species specific, not operating against S. " 04/01/1985 - "A single dose of Ro 11-3128 was found to be 98-100% effective against Schistosoma mansoni infections at intervals of 3 h to 15 days following infection, and apparently killed the schistosomula stages soon after administration, thus allowing an assessment of the immunizing potential of progressive larval stages. " 08/01/1989 - "Partial resistance to reinfection developed in mice with immature infections of Schistosoma mansoni treated with the drug Ro11-3128, whereas mice vaccinated with irradiated cercariae and treated in a similar way did not become immune. " 07/01/1994 - "Treatment of mice with the benzodiazepine derivative Ro11-3128 1-2 days post-infection with Schistosoma mansoni leads to arrest of virtually all schistosomula at the skin stage, and results in the development of protective immunity to challenge infection. "
2.	Schistosomiasis mansoni 07/01/1994 - "Resistance induced by drug abbreviated Schistosoma mansoni infections: treatment with the drug Ro11-3128 leads to enhanced antigen presentation." 04/01/1985 - "A single dose of Ro 11-3128 was found to be 98-100% effective against Schistosoma mansoni infections at intervals of 3 h to 15 days following infection, and apparently killed the schistosomula stages soon after administration, thus allowing an assessment of the immunizing potential of progressive larval stages. " 04/01/1985 - "Resistance following drug attenuation (Ro 11-3128 or oxamniquine) of early Schistosoma mansoni infections in mice."
3.	Blister (Bulla) 07/01/1994 - "A characteristic feature of Ro11-3128 treatment in vitro is the formation of exudates and membranous blebs at the schistosomular surface; other drugs tested, such as Ro15-5458 and oxamniquine which are also effective against the skin stages but relatively ineffective in inducing protection, do not induce this reaction. "
4.	Schistosomiasis (Bilharziasis) 04/14/1979 - "Preliminary results in human schistosomiasis with Ro 11-3128." 01/01/1985 - "The novel benzodiazepine derivative, meclonazepam (3-methylclonazepam) has been found to be orally effective at high doses against all stages of schistosomiasis. "
5.	Paralysis (Palsy) 01/01/2008 - "The benzodiazepine Ro 11-3128 (methyl-clonazepam) presents several similarities with praziquantel with regard to its anti-schistosomal mode of action, since both drugs cause spastic paralysis, calcium influx and tegumental disruption in the parasites. "

Related Drugs and Biologics

1.	Oxamniquine
2.	Ro 15-5458
3.	Benzodiazepines
4.	Vaccines
5.	Praziquantel (Biltricide)
6.	Clonazepam (Rivotril)
7.	Calcium
8.	Surface Antigens (Surface Antigen)
9.	Antigens