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GDPmannose dehydrogenase

Also Known As:

GDP-alpha-D-mannose oxidoreductase; GDP-mannose dehydrogenase

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - Carbohydrate Dehydrogenases
        GDPmannose dehydrogenase: 4

Related Diseases

1.

Cystic Fibrosis (Mucoviscidosis)

10/31/1989 - "The triggering of mucoidy (formation of the exopolysaccharide alginate) in Pseudomonas aeruginosa is accomplished primarily in Cystic Fibrosis lung environment through activation of the promoter of a gene algD, which encodes GDP-mannose dehydrogenase, by the product of a regulatory gene algR1. "
01/01/1994 - "The algD gene encodes NAD-linked GDPmannose dehydrogenase, which is essential for the mucoid phenotype, an important virulence factor expressed by Pseudomonas aeruginosa in cystic fibrosis patients. "
02/01/1983 - "GDPmannose dehydrogenase (EC 1.1.1.132) in a mucoid strain of Pseudomonas aeruginosa isolated from a patient with cystic fibrosis was identified by demonstrating the NAD-linked formation of GDPmannuronate from GDPmannose mediated by a cell extract of the organism. "
07/01/1987 - "The specific activities of phosphomannose isomerase (PMI), phosphomannomutase (PMM), GDP-mannose pyrophosphorylase (GMP), and GDP-mannose dehydrogenase (GMD) were compared in a mucoid cystic fibrosis isolate of Pseudomonas aeruginosa and in two spontaneous nonmucoid revertants. "

Related Drugs and Biologics

1.	NAD (NADH)
2.	Virulence Factors (Pathogenicity Factors)
3.	Mannose-6-Phosphate Isomerase (Mannose 6 Phosphate Isomerase)
4.	Cell Extracts
5.	Alginates
6.	phosphomannomutase
7.	mannose 1-phosphate guanylyltransferase