oligomycin sensitivity-conferring protein (complex V)

one subunit of whole ATPase complex of mitochondria, binding F(1) sector of ATPase complex to membrane sector; see also ATPase-binding protein (26,500)
Also Known As:
complex V; ATP50 ATP synthase subunit; OS-ATPase complex; OSCP protein; oligomycin sensitivity conferring protein; oligomycin-sensitive ATPase
Networked: 51 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Kofler, Barbara: 2 articles (04/2014 - 06/2004)
2. Sperl, Wolfgang: 2 articles (04/2014 - 06/2004)
3. Zeviani, Massimo: 2 articles (10/2013 - 01/2006)
4. Máximo, Valdemar: 2 articles (01/2012 - 05/2002)
5. Klussmann, Jens P: 1 article (11/2015)
6. Schilder, Sarah: 1 article (11/2015)
7. Guntinas-Lichius, Orlando: 1 article (11/2015)
8. Preuss, Simon F: 1 article (11/2015)
9. Schmidt, Matthias: 1 article (11/2015)
10. Wiesner, Rudolf J: 1 article (11/2015)

Related Diseases

1. Carcinoma (Carcinomatosis)
2. Mitochondrial Diseases (Mitochondrial Disease)
11/01/2011 - "This study demonstrates that the role of complex V in mitochondrial cristae morphology applies to human mitochondrial disease pathology."
07/01/2013 - "[Mitochondrial disorders associated with mitochondrial respiratory chain complex V deficiency]."
10/01/2013 - "Peripheral neuropathies with different phenotypic presentations occur in mitochondrial diseases associated with abnormalities in mitochondrial DNA replication and maintenance, or associated with defects in mitochondrial respiratory chain complex V. Our knowledge of mitochondrial disorders is rapidly growing as new nuclear genes are identified and new phenotypes described. "
06/27/1997 - "The method allowed us to study the protonophoric activities of both complex I and complex V following the fluorescence quenching of the monoamine 9-amino-6-chloro-2 methoxyacridine (ACMA), a probe highly sensitive to the generation of a transmembrane delta pH. We carried out a kinetic analysis of each enzyme complex studying the proton translocation and the electron transfer activities of complex I as well as the proton translocation and the ATP hydrolytic activities of complex V. A micromethod to prepare coupled submitochondrial particles from platelets might be useful to investigate cell bioenergetic damage occurring in mitochondrial diseases and ageing."
08/01/2014 - "In all patients, muscle biopsy showed ragged-red and cytochrome c oxidase-negative fibres with combined respiratory chain deficiency and abnormal assembly of complex V. The multiple mitochondrial DNA deletions found in skeletal muscle revealed a mitochondrial DNA instability disorder. "
3. Ataxia (Dyssynergia)
4. Neoplasms (Cancer)
5. Retinitis Pigmentosa (Pigmentary Retinopathy)

Related Drugs and Biologics

1. Mitochondrial DNA (mtDNA)
2. Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)
3. Adenosine Triphosphate (ATP)
4. Protons (Proton)
5. Adenosine Triphosphatases (ATPase)
6. Citrate (si)-Synthase (Synthase, Citrate)
7. oligomycin sensitivity-conferring protein (complex V)
8. Mitochondrial Proton-Translocating ATPases (Mitochondrial ATP Synthase)
9. Pyruvic Acid (Pyruvate)
10. Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1. Therapeutics
2. Transplantation (Transplant Recipients)