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monoacetoacetin

used as ketone body-carbohydrate substrate for parental feeding of rats

Also Known As:

monoglyceryl acetoacetate; Butanoic acid, 3-oxo-, monoester with 1,2,3-propanetriol

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Ketone Bodies: 1111
    - Acetoacetates: 1
      - monoacetoacetin: 6
- Carboxylic Acids: 973
  - Keto Acids: 203
    - Acetoacetates: 1
      - monoacetoacetin: 6
Lipids: 114793
- Glycerides: 109
  - monoacetoacetin: 6

Experts

1.	Hirakawa, Kosei: 1 article (07/2004)
2.	Nishiguchi, Yukio: 1 article (07/2004)
3.	Ohira, Masaichi: 1 article (07/2004)
4.	Sawai, Masamitsu: 1 article (07/2004)
5.	Yashiro, Masakazu: 1 article (07/2004)

Related Diseases

1.	Atrophy 04/01/1988 - "Inhibition of TPN-associated intestinal mucosal atrophy with monoacetoacetin." 04/01/1988 - "Thus, the substitution of monoacetoacetin for glucose calories in parenteral nutrition solutions inhibited TPN-related atrophy of intestinal mucosa while maintaining normal growth." 04/01/1988 - "The purpose of this study was to determine whether replacement of a portion of glucose calories with monoacetoacetin, the glycerol ester of acetoacetate, could inhibit TPN-associated intestinal atrophy. "
2.	Body Weight (Weight, Body) 03/01/1978 - "The nutritional properties of monoacetoacetin were investigated by continuous intravenous infusion of 25 or 50 g/kg body weight per day into ad libitum fed rats. " 09/01/1984 - "Body weight and urinary nitrogen were followed for 7 days, and leucine kinetics was measured on day 7. At 11 or 21 kcal/day, rats infused with the monoacetoacetin or the glucose-glycerol mixture had similar body weight losses, urinary nitrogen losses, leucine flux and leucine oxidation rates. "
3.	Weight Gain 07/01/1979 - "It was concluded from these data that intravenous monoacetoacetin can support weight gain in rats and is a potential alternative to glucose as an energy source in parenteral nutrition."
4.	Wounds and Injuries (Trauma) 01/01/1986 - "Comparison of monoglyceryl acetoacetate and glucose as parental energy substrate after experimental trauma."
5.	Stomach Neoplasms (Stomach Cancer) 07/01/2004 - "Growth-inhibitory effects of the ketone body, monoacetoacetin, on human gastric cancer cells with succinyl-CoA: 3-oxoacid CoA-transferase (SCOT) deficiency."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Glycerol (Glycerine)
3.	Esters
4.	acetoacetic acid (acetoacetate)
5.	Parenteral Nutrition Solutions
6.	Monoglycerides
7.	Transferases
8.	Nitrogen
9.	Leucine (L-Leucine)
10.	Ketones

Related Therapies and Procedures

1.	Parenteral Nutrition
2.	Intravenous Infusions