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isobutyryl-1-carnitine

Also Known As:

isobutyrylcarnitine; (S)-3-carboxy-N,N,N-trimethyl-2-(2-methyl-1-oxopropoxy)-1-propanaminium, hydroxide, inner salt

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Quaternary Ammonium Compounds: 136
    - Trimethyl Ammonium Compounds: 1
      - Carnitine: 4291
        isobutyryl-1-carnitine: 5

Experts

1.	Amano, Ikuko: 1 article (11/2021)
2.	Hatanaka, Yusuke: 1 article (11/2021)
3.	Ikuno, Masashi: 1 article (11/2021)
4.	Matsuzawa, Shu-Ichi: 1 article (11/2021)
5.	Takahashi, Ryosuke: 1 article (11/2021)
6.	Uemura, Norihito: 1 article (11/2021)
7.	Yamakado, Hodaka: 1 article (11/2021)
8.	Chalé, Angela: 1 article (10/2014)
9.	Fielding, Roger A: 1 article (10/2014)
10.	Lustgarten, Michael S: 1 article (10/2014)

Related Diseases

1.	Lacunar Stroke 01/01/2023 - "Isobutyrylcarnitine was positively associated with an increased risk of lacunar stroke. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 11/20/2021 - "Increased levels of isobutyrylcarnitine in p-PD mice imply an abnormality in β-oxidation in mitochondria, and increased levels of pyrimidine nucleoside can be associated with mitochondrial dysfunction. "
3.	Insulin Resistance 10/01/2014 - "Metabolites related to gut bacterial metabolism (cinnamoylglycine, phenol sulfate, p-cresol sulfate, 3-indoxyl sulfate, serotonin, N-methylproline, hydrocinnamate, dimethylglycine, trans-urocanate, valerate) that are altered in response to peroxisome proliferator-activated receptor-alpha (PPAR-α) activation (α-hydroxyisocaproate, α-hydroxyisovalerate, 2-hydroxy-3-methylvalerate, indolelactate, serotonin, 2-hydroxypalmitate, glutarylcarnitine, isobutyrylcarnitine, cinnamoylglycine) and that are related to insulin sensitivity (monounsaturated fatty acids: 5-dodecenoate, myristoleate, palmitoleate; γ-glutamylamino acids: γ-glutamylglutamine, γ-glutamylalanine, γ-glutamylmethionine, γ-glutamyltyrosine; branched-chain amino acids: leucine, isoleucine, valine) were associated with function at baseline, with the 6-month change in function or were identified in backward elimination regression predictive models. "
4.	Ethylmalonic encephalopathy 10/01/2006 - "Persistent increase of plasma butyryl/isobutyrylcarnitine concentrations as marker of SCAD defect and ethylmalonic encephalopathy."
5.	Isobutyryl-CoA dehydrogenase deficiency 08/01/2003 - "Since then, three infants with short-chain acyl-CoA dehydrogenase (SCAD) and one with isobutyryl-CoA dehydrogenase deficiency were detected on the basis of elevated butyrylcarnitine/isobutyrylcarnitine (C4-carnitine) concentrations in newborn blood spots analyzed by tandem mass spectrometry. "

Related Drugs and Biologics

1.	PPAR alpha
2.	Peroxisome Proliferator-Activated Receptors (PPAR)
3.	Butyryl-CoA Dehydrogenase (Short-Chain Acyl-CoA Dehydrogenase)
4.	Phenol (Carbolic Acid)
5.	Valine (L-Valine)
6.	Valerates
7.	Sulfates (Sulfates, Inorganic)
8.	Serotonin (5 Hydroxytryptamine)
9.	Nucleosides
10.	Leucine (L-Leucine)