diethanolamine

RN given refers to parent cpd

Also Known As:

diethanolamine acetate; diethanolamine bisulfate; diethanolamine fumarate; diethanolamine hydrochloride; diethanolamine maleate; diethanolamine maleate (1:1); diethanolamine phosphate; diethanolamine sulfate (1:1); diethanolamine sulfate (2:1); diethanolamine sulfite; diethanolamine sulfite (1:1); diethanolammonium sulfate; 2,2'-iminobisethanol

Networked: 40 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Ethanolamines: 16
      - diethanolamine: 40
- Alcohols: 595
  - Ethanol: 23169
    - Ethanolamines: 16
      - diethanolamine: 40
  - Amino Alcohols: 20
    - Ethanolamines: 16
      - diethanolamine: 40

Experts

1.	Kamendulis, Lisa M: 3 articles (04/2006 - 10/2005)
2.	Ichihara, Hideaki: 2 articles (01/2019 - 01/2014)
3.	Matsumoto, Yoko: 2 articles (01/2019 - 01/2014)
4.	Bai, Cui-Gai: 1 article (12/2019)
5.	Bai, Wen-Fei: 1 article (12/2019)
6.	Gao, Yuan: 1 article (12/2019)
7.	Sun, Tong-Yan: 1 article (12/2019)
8.	Liu, Yang: 1 article (01/2019)
9.	Motomura, Muneaki: 1 article (01/2019)
10.	Wang, Dong: 1 article (01/2019)

Related Diseases

1.	Alcoholic Fatty Liver 08/01/2000 - "In conclusion, the 8-week treatment with betaine glucuronate combined with diethanolamine glucuronate and nicotinamide ascorbate was found effective in non-alcoholic steatohepatitis, a disorder for which the hitherto pharmacological interventions were poorly and inconsistently effective."
2.	Neoplasms (Cancer) 04/01/2016 - "Diethanolamine (DEA) has been found to produce liver and kidney tumors in mice following lifetime dermal exposures. " 04/01/2006 - "Diethanolamine (DEA), a non-genotoxic alkanolamine, produces liver tumors in mice. " 10/01/2005 - "Diethanolamine increased the incidence and multiplicity of liver tumors in the mouse following chronic exposure. " 07/01/1999 - "CONCLUSIONS: Under the conditions of these 2-year dermal studies, there was no evidence of carcinogenic activity of diethanolamine in male F344/N rats administered 16, 32, or 64 mg/kg diethanolamine or in female F344/N rats administered 8, 16, or 32 mg/kg. There was clear evidence of carcinogenic activity of diethanolamine in male and female B6C3F1 mice based on increased incidences of liver neoplasms in males and females and increased incidences of renal tubule neoplasms in males. " 12/15/2003 - "Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years."
3.	Carcinogenesis 07/01/1999 - "NTP Toxicology and Carcinogenesis Studies of Diethanolamine (CAS No. 111-42-2) in F344/N Rats and B6C3F1 Mice (Dermal Studies)." 07/01/1999 - "NTP Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CAS NO. 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)." 07/01/1999 - "NTP Toxicology and Carcinogenesis Studies of Oleic Acid Diethanolamine Condensate (CAS No. 93-83-4) in F344/N Rats and B6C3F1 Mice (Dermal Studies)." 01/01/2001 - "Toxicology and carcinogenesis studies of coconut oil acid diethanolamine condensate (CAS No. 68603-42-9) in F344/N rats and B6C3F1 mice (dermal studies)."
4.	Body Weight (Weight, Body) 07/01/1999 - "MICE: Groups of 50 male and 50 female mice were administered 0, 40, 80, or 160 mg diethanolamine/kg body weight in ethanol dermally for 2 years. " 07/01/1999 - "RATS: Groups of 50 male rats were administered 0, 16, 32, or 64 mg diethanolamine/kg body weight in ethanol dermally for 2 years. " 07/01/1999 - "2-YEAR STUDY IN MICE: Groups of 50 male and 50 female mice were admin istered 0, 100, or 200 mg lauric acid diethanolamine condensate/kg body weight in ethanol by dermal application for 105 or 106 weeks. " 07/01/1999 - "2-YEAR STUDY IN RATS: Groups of 50 male and 50 female rats were admin istered 0, 50, or 100 mg lauric acid diethanolamine condensate/kg body weight in ethanol by dermal application for 104 or 105 weeks. " 07/01/1999 - "14-WEEK STUDY IN MICE: Groups of 10 male and 10 female mice were admin istered 0, 50, 100, 200, 400, or 800 mg lauric acid diethanolamine condensate/kg body weight in ethanol by dermal application for 14 weeks. "
5.	Inflammation (Inflammations) 01/01/1994 - "Exposure to diethanolamine caused dose-dependent toxic effects in the liver (hepatocellular cytological alterations and necrosis), kidney (nephropathy and tubular epithelial necrosis in males), heart (cardiac myocyte degeneration) and skin (site of application: ulceration, inflammation, hyperkeratosis, and acanthosis). " 01/01/1994 - "Dose-dependent toxic effects due to exposure to diethanolamine included hematological changes (a poorly regenerative, microcytic anemia), as well as toxic responses in the kidney (increased weight, tubular necrosis, decreased renal function, and/or tubular mineralization), brain and spinal cord (demyelination), testis (degeneration of the seminiferous tubules) and skin (site of application: ulceration, inflammation, hyperkeratosis and acanthosis). " 07/01/1999 - "CONCLUSIONS: Under the conditions of these 2-year dermal studies, there was no evidence of carcinogenic activity of oleic acid diethanolamine condensate in male or female F344/N rats administered 50 or 100 mg/kg or in male or female B6C3F1 mice administered 15 or 30 mg/kg. Dermal administration of oleic acid diethanolamine condensate to male and female rats was associated with epidermal hyperplasia, sebaceous gland hyper plasia, hyperkeratosis, parakeratosis, chronic active inflammation of the dermis, and ulceration of the skin at the site of application. " 07/01/1999 - "Dermal administration of lauric acid diethanolamine condensate to rats and mice for 2 years resulted in increased incidences of epidermal and sebaceous gland hyperplasia, hyperkeratosis, chronic inflammation, and parakeratosis at the site of application. " 09/13/2023 - "Diethanolamine increases interleukin 6 (IL-6), IL-8, interferon γ-induced protein 10 kDa (IP-10), growth-regulated oncogene (GRO), fractalkine, matrix metalloproteinase 1 (MMP-1), MMP-9 and MMP-10 (p < 0.05 for all), factors involved in acute inflammation and recruitment of monocytes, neutrophils and lymphocytes. "

Related Drugs and Biologics

1.	Glucuronic Acid (Glucuronate)
2.	Niacinamide (Nicotinamide)
3.	betaine glucuronate
4.	Ethanol (Ethyl Alcohol)
5.	Oleic Acid (Oleate)
6.	Proteins (Proteins, Gene)
7.	Acids
8.	beta Catenin
9.	Buffers
10.	Coconut Oil

Related Therapies and Procedures

1.	Cutaneous Administration