dendrotoxin

05/11/1992 - "Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker."
01/01/1987 - "When dendrotoxin was microinjected in the amygdala or the hippocampus, the seizures appeared at the injection sites with a shorter latency and the bioelectrical epileptic signs lasted longer than when injections were given in non-limbic structures, such as the globus pallidus or the mesencephalic reticular formation. "
04/01/1996 - "In conclusion, the present data on dendrotoxin K, together with the previously described pattern of neurotoxicity for alpha-dendrotoxin, show that these homologues act via different mechanisms and, thus, can be used effectively as complementary tools to study seizures and neuronal cell death."
03/13/1992 - "Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs."
07/04/2003 - "In this study, we investigated the effects of 2 weeks ad libitum consumption of guanosine (0.5 mg/ml) added to mice water supply on seizures and lethality induced by the alpha-dendrotoxin, hole-board behavior, inhibitory avoidance task, locomotor activity, motor coordination, rectal temperature, body weight, and water and food consumption. "

09/01/2023 - "Finally, we analysed that 12-oleanen-3yl acetate,3-α (CID-45044112) a triterpenoid showing a maximum binding affinity with all snake venom proteins (-13.8k/cal) with Phospholipase A2 (PLA2), Cardiotoxin-II (-8.2k/cal), Dendrotoxin (-12.1 k/cal), Cardiotoxin-III (-8.2 kcal/mol) and alpha-Neurotoxin (-11.0 kcal/mol), which may have potential to counteract the adverse effects caused by snakebites, however, in-vitro and in-vivo studies still challenging tasks for our further analysis. "

03/01/2011 - "In the present study, we investigated the effects of the Kv1.1-specific blocker, dendrotoxin-κ (DTX-κ, on tumor formation induced by the human lung adenocarcinoma cell line A549 in a xenograft model. "
03/01/2011 - "Dendrotoxin-κ suppresses tumor growth induced by human lung adenocarcinoma A549 cells in nude mice."

03/01/2011 - "In the present study, we investigated the effects of the Kv1.1-specific blocker, dendrotoxin-κ (DTX-κ, on tumor formation induced by the human lung adenocarcinoma cell line A549 in a xenograft model. "
03/01/2011 - "Dendrotoxin-κ suppresses tumor growth induced by human lung adenocarcinoma A549 cells in nude mice."

01/01/2003 - "Dendrotoxin poisoning in a neurobiochemist."
12/15/1995 - "Both apamin and dendrotoxin injected intracerebroventricularly produced signs of poisoning, including tremor and ataxia; however, only DTx produced changes in brain electrical activity, with high voltage spikes and epileptiform activity and subsequent brain damage. "