4-chlorophenylalanine methyl ester

RN given refers to parent cpd without isomeric designation

Also Known As:

4-chlorophenylalanine methyl ester, (DL)-isomer; 4-chlorophenylalanine methyl ester, hydrochloride; 4-chlorophenylalanine methyl ester, hydrochloride, (D)-isomer; 4-chlorophenylalanine methyl ester, hydrochloride, (DL)-isomer; p-chlorophenylalanine methyl ester; para-chlorophenylalanine methyl ester

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Cyclic Amino Acids: 3
    - Aromatic Amino Acids: 467
      - Phenylalanine: 4090
        Fenclonine: 283
        4-chlorophenylalanine methyl ester: 2

Experts

1.	Carvalho, João E: 1 article (04/2011)
2.	Foglio, Mary A: 1 article (04/2011)
3.	Rodrigues, Rodney A F: 1 article (04/2011)
4.	Servat, Leila: 1 article (04/2011)
5.	Sousa, Ilza M O: 1 article (04/2011)
6.	Spindola, Humberto M: 1 article (04/2011)

Related Diseases

1.	Pain (Aches) 04/10/2011 - "The present study demonstrated that when administered intraperitoneally (i.p.): i), compounds C1 and C2 produced significant anti-allodynic activity during the acute phase of the Complete Freund's Adjuvant (CFA)-induced persistent pain model; ii) compound C1 produced significant anti-hypernociception activity in the carrageenan-induced pain model; iii) compound C2 presented a significant loss of activity after p-chlorophenylalanine methyl ester hydrochloride (PCPA) [5-HT synthesis inhibitor] treatment, suggesting that the mechanisms of action could be related to either the synthesis or release of serotonin; iv) compound C1 presented a significant loss of activity after ondansetron (5-HT(3) receptor antagonist) treatment suggesting activity upon 5-HT(3) serotonin receptors; v) compound C1 presented a significant loss of activity after efaroxan (mixed I(1) imidazoline/α(2)-adrenoceptor antagonist) treatment suggesting the participation of this compound upon imidazoline I(1) receptors; and vi) both compounds C1 and C2 did not appear to exert their activity via 5-HT(1A), 5-HT(2A), imidazoline I(2), α(2)-adrenoceptor, nitric oxide, GABA(A), acetylcholine muscarinic, and nicotinic receptors when evaluated in acetic acid-induced nociception."
2.	Phenylketonurias (Phenylketonuria) 01/01/1989 - "Intraperitoneal injections of para-Chlorophenylalanine methyl ester and Phenylalanine solution were used to produce phenylketonuria in rats. "

Related Drugs and Biologics

1.	Imidazolines
2.	Acetic Acid (Vinegar)
3.	Cholinergic Agents (Cholinergics)
4.	Ondansetron (Zofran)
5.	Serotonin (5 Hydroxytryptamine)
6.	Serotonin Receptors
7.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
8.	Adrenergic Receptors (Adrenergic Receptor)
9.	Nitric Oxide (Nitrogen Monoxide)
10.	gamma-Aminobutyric Acid (GABA)

Related Therapies and Procedures

1.	Intraperitoneal Injections