brivudine (brivudin)

anti-herpes agent; (Z)-isomer much less active against herpes simplex virus type 1 & somewhat less active against herpes simplex virus type 2 than is the (E)-isomer; both isomers show similar activity against vaccinia virus; RN given refers to (E)-trans-isomer; structure
Also Known As:
brivudin; (E)-5-(2-bromovinyl)-2'-deoxyuridine; (Z)-5-(2-bromovinyl)-2'-deoxyuridine; 5-(2-bromoethenyl)-2'-deoxyuridine; 5-(2-bromovinyl)-2'-deoxyuridine; 5-BVDU; Berlin-Chemie brand of brivudine; E-5-(2-bromovinyl)-dUrd; Z-5-(2-bromovinyl)-dUrd; Zostex; Uridine, 5-(2-bromoethenyl)-2'-deoxy-, (E)-
Networked: 100 relevant articles (18 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. De Clercq, E: 6 articles (12/2004 - 09/2000)
2. Balzarini, J: 4 articles (03/2012 - 02/2000)
3. De Clercq, Erik: 3 articles (07/2015 - 06/2004)
4. Degrève, B: 3 articles (02/2001 - 02/2000)
5. Topalis, Dimitri: 2 articles (12/2014 - 11/2008)
6. Wassilew, S: 2 articles (05/2010 - 04/2003)
7. Balzarini, Jan: 2 articles (11/2008 - 08/2005)
8. Brivddin Herpes Zoster Study Group: 2 articles (06/2003 - 06/2003)
9. Wutzler, Peter: 2 articles (06/2003 - 06/2003)
10. Wassilew, Sawko W: 2 articles (06/2003 - 06/2003)

Related Diseases

1. Herpes Zoster
2. Infection
3. Pain (Aches)
4. Postherpetic Neuralgia
5. Chickenpox
08/01/1984 - "The antiviral activity spectrum of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) is not restricted to herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) but also encompasses several other herpesviruses such as suid herpesvirus type 1 (SHV-1), bovid herpesvirus type 1 (BHV-1), simian varicella virus (SVV), herpesvirus saimiri, herpesvirus platyrrhinae, and the baculovirus Trichoplusia ni multiple nuclear polyhedrosis virus. "
03/01/1982 - "5-(2-Bromovinyl)-2'-deoxyuridine (BrVdUrd) is a potent and selective inhibitor of herpes simplex virus Type I (HS-I) and varicella zoster (VZ) virus replication but is much less potent against herpes simplex virus Type II (HS-II) replication. "
11/01/1991 - "All obviously immunocompromised children with varicella or zoster may be treated with aciclovir or brivudin."
02/01/2000 - "Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase."
07/01/1993 - "Agents available to treat herpesvirus infections include idoxuridine, trifluridine, vidarabine and acyclovir for the topical treatment of herpetic eye infections; vidarabine and acyclovir for the systemic (intravenous) treatment of herpes encephalitis; acyclovir for the topical and systemic (oral) treatment of genital herpes; acyclovir for the systemic (intravenous, oral) treatment of HSV or varicella-zoster (VZV) infections in immunosuppressed patients; brivudin for the systemic (oral) treatment of HSV-1 or VZV infections in immunosuppressed patients; and ganciclovir and foscarnet for the systemic (intravenous) treatment of cytomegalovirus (CMV) retinitis in AIDS patients. "

Related Drugs and Biologics

1. Acyclovir (Aciclovir)
2. famciclovir (Famvir)
3. Idoxuridine (Stoxil)
4. Foscarnet
5. Trifluridine (Viroptic)
6. valacyclovir (valaciclovir)
7. Vidarabine (Vira-A)
8. Ganciclovir (Cytovene)
9. brivudine (brivudin)
10. cidofovir (Vistide)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Intravitreal Injections
3. Stents
4. Kidney Transplantation
5. Transplantation (Transplant Recipients)