brivudine (brivudin)

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86 relevant articles (17 outcomes, 9 trials/studies) found for this Bio-Agent

Description: anti-herpes agent; (Z)-isomer much less active against herpes simplex virus type 1 & somewhat less active against herpes simplex virus type 2 than is the (E)-isomer; both isomers show similar activity against vaccinia virus; RN given refers to (E)-trans-isomer; structure

Also Known As:

brivudin; (E)-5-(2-bromovinyl)-2'-deoxyuridine; (Z)-5-(2-bromovinyl)-2'-deoxyuridine; 5-(2-bromoethenyl)-2'-deoxyuridine; 5-(2-bromovinyl)-2'-deoxyuridine; 5-BVDU; Berlin-Chemie brand of brivudine; E-5-(2-bromovinyl)-dUrd; Z-5-(2-bromovinyl)-dUrd; Zostex; Uridine, 5-(2-bromoethenyl)-2'-deoxy-, (E)-

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

1-Ring Heterocyclic Compounds

Pyrimidines: 269

Pyrimidine Nucleosides: 38

Uridine: 756

Deoxyuridine: 233

Bromodeoxyuridine: 2250

brivudine: 86

Nucleic Acids, Nucleotides, and Nucleosides: 1

Nucleosides: 591

Pyrimidine Nucleosides: 38

Uridine: 756

Deoxyuridine: 233

Bromodeoxyuridine: 2250

brivudine: 86

Deoxyribonucleosides: 28

Deoxyuridine: 233

Bromodeoxyuridine: 2250

brivudine: 86

Experts

1.	De Clercq, E: 2 articles (12/2004 - 09/2000)
2.	Wutzler, Peter: 2 articles (06/2003 - 06/2003)
3.	Wassilew, Sawko W: 2 articles (06/2003 - 06/2003)
4.	Brivddin Herpes Zoster Study Group: 2 articles (06/2003 - 06/2003)
5.	Pereira, Teresa: 1 article (01/2008)
6.	Correia, Osvaldo: 1 article (01/2008)
7.	Pereira, Marta A: 1 article (01/2008)
8.	Santos, Antonio: 1 article (01/2008)
9.	Santos, António: 1 article (01/2008)
10.	Chavaz, P: 1 article (02/2006)

Related Diseases

1.	Herpes Zoster 01/01/2008 - "We report the case of an 8-year-old immunocompetent boy with a painful lumbosacral herpes zoster that was treated with brivudin and achieved rapid and sustained improvement in the absence of muco-cutaneous or pharmacological side effects." 12/15/2004 - "Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster." 06/01/2003 - "Despite some methodological disadvantages common to this type of study, the present survey provides for the first evidence that brivudin treatment during acute herpes zoster favourably affects the incidence of PHN in immunocompetent elderly herpes zoster patients." 01/01/2008 - "Perineal muco-cutaneous herpes zoster treated with brivudin." 11/01/1980 - "Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine in severe herpes zoster." Get all the results and reference details, order at left...
2.	Infection 04/16/1999 - "(E)-5-(2-Bromovinyl)-2'-deoxyuridine is an antiviral drug used for treatment of infections with Herpes simplex virus type 1 as well as Varicella zoster virus" 06/01/1985 - "Preclinical assessment of topical treatments of herpes simplex virus infection: 5% (E)-5-(2-bromovinyl)-2'-deoxyuridine cream." 01/01/1985 - "Therapy of varicella-zoster virus infection--mechanism of action of (E)-5-(2-bromovinyl)-2'-deoxyuridine." 08/01/1984 - "Topical treatment of cutaneous herpes simplex virus infection in hairless mice with (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds." 01/01/1984 - "Effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on several parameters of Epstein-Barr virus infection." Get all the results and reference details, order at left...
3.	Pain (Aches) 01/01/2005 - "CONCLUSIONS: The study demonstrated equivalent efficacy of brivudin and famciclovir in the treatment of herpes zoster regarding the prevention of chronic pain and the resolution of signs and symptoms of acute herpes zoster" 01/01/2004 - "In a large, 7-day, phase III trial in immunocompetent patients with herpes zoster, once-daily brivudin 125mg was significantly more effective than oral acyclovir 800mg five times daily in reducing the mean time from start of treatment to last vesicular eruption, and was as effective as acyclovir at healing lesions and alleviating acute zoster-related pain" 01/01/2003 - "Brivudine 125mg once daily is as effective as famciclovir 250mg three times daily in reducing the prevalence and the duration of zoster-associated pain and postherpetic neuralgia, especially if therapy is combined with a structured-pain therapy" 01/01/2005 - "Brivudin compared with famciclovir in the treatment of herpes zoster: effects in acute disease and chronic pain in immunocompetent patients" 06/01/2003 - "The incidence of PHN, defined as zoster-associated pain occurring or persisting after rash healing was significantly lower in brivudin recipients (32.7%) than in acyclovir recipients (43.5%, P=0.006)" Get all the results and reference details, order at left...
4.	Postherpetic Neuralgia 06/01/2003 - "Oral brivudin in comparison with acyclovir for herpes zoster: a survey study on postherpetic neuralgia." 01/01/2003 - "Brivudine 125mg once daily is as effective as famciclovir 250mg three times daily in reducing the prevalence and the duration of zoster-associated pain and postherpetic neuralgia, especially if therapy is combined with a structured-pain therapy" 01/01/2003 - "Valaciclovir (valacyclovir), famciclovir and brivudine (brivudin) are comparably effective in the reduction of the incidence and/or prevention of zoster-associated pain and postherpetic neuralgia" Get all the results and reference details, order at left...
5.	Chickenpox 08/01/1984 - "The antiviral activity spectrum of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) is not restricted to herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) but also encompasses several other herpesviruses such as suid herpesvirus type 1 (SHV-1), bovid herpesvirus type 1 (BHV-1), simian varicella virus (SVV), herpesvirus saimiri, herpesvirus platyrrhinae, and the baculovirus Trichoplusia ni multiple nuclear polyhedrosis virus" 03/01/1982 - "5-(2-Bromovinyl)-2'-deoxyuridine (BrVdUrd) is a potent and selective inhibitor of herpes simplex virus Type I (HS-I) and varicella zoster (VZ) virus replication but is much less potent against herpes simplex virus Type II (HS-II) replication" 11/01/1991 - "All obviously immunocompromised children with varicella or zoster may be treated with aciclovir or brivudin." 02/01/2000 - "Comparative in vitro and in vivo cytotoxic activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and its arabinosyl derivative, (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), against tumor cells expressing either the Varicella zoster or the Herpes simplex virus thymidine kinase." 07/01/1993 - "Agents available to treat herpesvirus infections include idoxuridine, trifluridine, vidarabine and acyclovir for the topical treatment of herpetic eye infections; vidarabine and acyclovir for the systemic (intravenous) treatment of herpes encephalitis; acyclovir for the topical and systemic (oral) treatment of genital herpes; acyclovir for the systemic (intravenous, oral) treatment of HSV or varicella-zoster (VZV) infections in immunosuppressed patients; brivudin for the systemic (oral) treatment of HSV-1 or VZV infections in immunosuppressed patients; and ganciclovir and foscarnet for the systemic (intravenous) treatment of cytomegalovirus (CMV) retinitis in AIDS patients" Get all the results and reference details, order at left...
47 Diseases and 86 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Acyclovir (Aciclovir)
2.	famciclovir (Famvir)
3.	Idoxuridine (Stoxil)
4.	Foscarnet
5.	Trifluridine (Viroptic)
6.	Vidarabine (Vira-A)
7.	Ganciclovir (Cytovene)
8.	brivudine (brivudin)
9.	valacyclovir (valaciclovir)
10.	cidofovir (Vistide)
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