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traxanox
RN given refers to parent cpd; structure
Also Known As:
9-chloro-5-oxo-7-(1H-tetrazol-5-yl)-5H-(1)benzopyrano(2,3-b)pyridine; Y 12,141; Y 12141; Y-12,141; Y-12141; traxanox hydrochloride; 5H-(1)Benzopyrano(2,3-b)pyridin-5-one, 9-chloro-7-(1H-tetrazol-5-yl)-, sodium salt
Networked:
10
relevant articles (
4
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Chromones: 159
traxanox: 10
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Chromones: 159
traxanox: 10
Related Diseases
1.
Asthma (Bronchial Asthma)
08/01/1980 - "
The present results suggest that Y-12,141 may be effective for the treatment of allergic bronchial asthma.
"
07/01/1983 - "
These results suggest that traxanox inhibits the release of SRS-A in vivo, so that it may be clinically effective in treating patients with allergic bronchial asthma.
"
2.
Hypersensitivity (Allergy)
07/01/1988 - "
These results suggest that traxanox may be clinically effective in treating patients with nasal allergies.
"
11/01/1985 - "
In experimental models of delayed type hypersensitivity (DTH), traxanox (100 mg/kg, p.o.) inhibited the accumulation of the exudate and the leucocyte migration in B.
"
07/01/1988 - "
[Effects of traxanox sodium on experimental nasal allergy].
"
12/01/1982 - "
[[Effect of traxanox sodium on type I-IV allergic reactions.
"
12/01/1982 - "
In conclusion, traxanox sodium is considered to have a wider spectrum of anti-allergic activity than DSCG since it has a suppressive effect not only on the type I allergic reaction, but also on the type III and IV allergic reactions.
"
3.
Rheumatoid Arthritis
11/01/1985 - "
These results indicate that the mode of action of traxanox on inflammatory responses resembles that of D-penicillamine or levamisole, so that it may prove to be clinically effective in treating rheumatoid arthritis.
"
4.
Lupus Nephritis
01/01/1985 - "
[Immuno-pharmacologic study of the effects of traxanox in lupus nephritis in MRL/l mice].
"
5.
Bone Resorption
01/01/1989 - "
In this study, we have investigated the in vitro effects of the immunomodulators lobenzarit and traxanox and a newly synthesized immunosuppressant, mizoribine, as well as cyclosporin A, on bone resorption using neonatal mouse calvariae labelled with 45Ca.
"
01/01/1989 - "
Basal bone resorption was inhibited by immunosuppressant cyclosporin A or mizoribine, while immunomodulators lobenzarit and traxanox failed to inhibit basal bone resorption.
"
01/01/1989 - "
Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1 beta or TNF-alpha in a dose-dependent manner.
"
Related Drugs and Biologics
1.
SRS-A
2.
Penicillamine (Cuprimine)
3.
Levamisole (Decaris)
4.
Cyclosporine (Ciclosporin)
5.
Immunosuppressive Agents (Immunosuppressants)
6.
Immunologic Factors (Immunomodulators)
7.
lobenzarit
8.
mizoribine
9.
Sodium
10.
Anti-Allergic Agents (Antiallergic Agents)