traxanox

RN given refers to parent cpd; structure

Also Known As:

9-chloro-5-oxo-7-(1H-tetrazol-5-yl)-5H-(1)benzopyrano(2,3-b)pyridine; Y 12,141; Y 12141; Y-12,141; Y-12141; traxanox hydrochloride; 5H-(1)Benzopyrano(2,3-b)pyridin-5-one, 9-chloro-7-(1H-tetrazol-5-yl)-, sodium salt

Networked: 10 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        traxanox: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        traxanox: 10

Related Diseases

1.	Asthma (Bronchial Asthma) 08/01/1980 - "The present results suggest that Y-12,141 may be effective for the treatment of allergic bronchial asthma." 07/01/1983 - "These results suggest that traxanox inhibits the release of SRS-A in vivo, so that it may be clinically effective in treating patients with allergic bronchial asthma."
2.	Hypersensitivity (Allergy) 07/01/1988 - "These results suggest that traxanox may be clinically effective in treating patients with nasal allergies." 11/01/1985 - "In experimental models of delayed type hypersensitivity (DTH), traxanox (100 mg/kg, p.o.) inhibited the accumulation of the exudate and the leucocyte migration in B. " 07/01/1988 - "[Effects of traxanox sodium on experimental nasal allergy]." 12/01/1982 - "[[Effect of traxanox sodium on type I-IV allergic reactions. " 12/01/1982 - "In conclusion, traxanox sodium is considered to have a wider spectrum of anti-allergic activity than DSCG since it has a suppressive effect not only on the type I allergic reaction, but also on the type III and IV allergic reactions."
3.	Rheumatoid Arthritis 11/01/1985 - "These results indicate that the mode of action of traxanox on inflammatory responses resembles that of D-penicillamine or levamisole, so that it may prove to be clinically effective in treating rheumatoid arthritis."
4.	Lupus Nephritis 01/01/1985 - "[Immuno-pharmacologic study of the effects of traxanox in lupus nephritis in MRL/l mice]."
5.	Bone Resorption 01/01/1989 - "In this study, we have investigated the in vitro effects of the immunomodulators lobenzarit and traxanox and a newly synthesized immunosuppressant, mizoribine, as well as cyclosporin A, on bone resorption using neonatal mouse calvariae labelled with 45Ca. " 01/01/1989 - "Basal bone resorption was inhibited by immunosuppressant cyclosporin A or mizoribine, while immunomodulators lobenzarit and traxanox failed to inhibit basal bone resorption. " 01/01/1989 - "Lobenzarit, traxanox, mizoribine and cyclosporin A inhibited or tended to inhibit bone resorption stimulated by PTH, LPS, IL-1 beta or TNF-alpha in a dose-dependent manner. "

Related Drugs and Biologics

1.	SRS-A
2.	Penicillamine (Cuprimine)
3.	Levamisole (Decaris)
4.	Cyclosporine (Ciclosporin)
5.	Immunosuppressive Agents (Immunosuppressants)
6.	Immunologic Factors (Immunomodulators)
7.	lobenzarit
8.	mizoribine
9.	Sodium
10.	Anti-Allergic Agents (Antiallergic Agents)