|1.||Munier-Lehmann, Hélène: 3 articles (12/2010 - 10/2006)|
|2.||Balzarini, Jan: 3 articles (10/2009 - 06/2002)|
|3.||Yanagisawa, Teruyuki: 2 articles (01/2015 - 01/2013)|
|4.||Medin, Jeffrey A: 2 articles (01/2015 - 01/2013)|
|5.||Sato, Takeya: 2 articles (01/2015 - 01/2013)|
|6.||Neschadim, Anton: 2 articles (01/2015 - 01/2013)|
|7.||Chang, Zee-Fen: 2 articles (07/2012 - 04/2008)|
|8.||Hu, Chun-Mei: 2 articles (07/2012 - 04/2008)|
|9.||Meyer, Philippe: 2 articles (10/2009 - 11/2008)|
|10.||Topalis, Dimitri: 2 articles (10/2009 - 11/2008)|
01/01/2014 - "Preventing the return of smallpox: molecular modeling studies on thymidylate kinase from Variola virus."
02/16/2015 - "Recently we constructed a homology model of the enzyme thymidylate kinase from Variola virus (VarTMPK) and proposed it as a new target to the drug design against smallpox. "
02/16/2015 - "Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox."
01/01/2014 - "Considering this threat and the non-existence of effective chemotherapy, we propose the enzyme thymidylate kinase from Variola virus (VarTMPK) as a potential target to the drug design against smallpox. "
01/01/2015 - "Evaluation of Bystander Cell Killing Effects in Suicide Gene Therapy of Cancer: Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis."
01/01/2013 - "The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer."
07/10/2012 - "Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair."
02/01/2006 - "The presented transgenic bacteria could be of interest for testing of thymidylate kinase-specific phosphorylation of nucleoside analogues that are used in therapies against cancer and infectious diseases."
11/04/2008 - "The brivudin monophosphate-bound structure explains the structural basis for this specificity, opening the way to the rational development of specific antipox agents that may also be suitable for poxvirus TMP kinase gene-based chemotherapy of cancer."
12/01/2010 - "Thymidine monophosphate kinase from Mycobacterium tuberculosis (TMPKmt) has been proposed as an attractive target in the search of new agents to fight against tuberculosis. "
10/01/2006 - "tuberculosis thymidylate kinase."
04/11/2003 - "Mycobacterium tuberculosis TMP kinase (TMPK(Mtub)) represents a promising target for developing drugs against tuberculosis because the configuration of its active site is unique in the TMPK family. "
06/01/2002 - "tuberculosis thymidylate kinase was found to have some activity. "
01/22/2015 - "tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors."
11/04/2008 - "The vaccinia TMP kinase dimer arrangement is orthogonal and not antiparallel as in human enzyme. "
11/01/2005 - "The accurate mass data, in conjunction with MS/MS data, was able to identify the sequence IVIEAIHTV (aa 187-195) from the protein thymidylate kinase of vaccinia, distinguishing it from a similar sequence IVLEAIAEH: a "self-peptide" from the human protein phospholipase Cbeta3. "
10/09/2009 - "All tested nucleotides are found surprisingly substrates of vaccinia TMP kinase and also of human GMP kinase. "
10/09/2009 - "Alkylated and oxidized dGMP analogs were examined as potential substrates for vaccinia TMP kinase and also for human TMP and GMP kinases. "
10/01/2007 - "Analysis of differential gene expression in salmon (Salmo salar) blood following infection with the monogenean parasite Gyrodactylus salaris, resulted in the isolation of a thymidylate kinase gene not previously described from fish and which showed similarity to an LPS-inducible thymidylate kinase gene isolated from mouse macrophages. "
10/01/2007 - "Isolation of a novel fish thymidylate kinase gene, upregulated in Atlantic salmon (Salmo salar L.) following infection with the monogenean parasite Gyrodactylus salaris."
02/01/1989 - "Despite the low levels of tk and TMP kinase activity expressed by KG111, this mutant established reactivatable latent infections as efficiently as wild-type virus in a mouse model."
06/01/2000 - "SHIV infection, or associated pathophysiological disorders, increase both thymidine kinase and thymidylate kinase mRNA expression and decrease those of P-gp. "
|2.||DNA (Deoxyribonucleic Acid)
|5.||DCMP Deaminase (Deoxycytidylate Deaminase)
|6.||Thymidine Monophosphate (TMP)
|1.||Drug Therapy (Chemotherapy)