|1.||Fearns, Rachel: 1 article (07/2015)|
|2.||Dickey, Laura L: 1 article (07/2015)|
|3.||Hanley, Timothy M: 1 article (07/2015)|
|4.||Duncan, Julie K: 1 article (07/2015)|
|5.||Fernández-Carrillo, Carlos: 1 article (04/2015)|
|6.||Miquel, Rosa: 1 article (04/2015)|
|7.||Pérez-del-Pulgar, Sofía: 1 article (04/2015)|
|8.||Forns, Xavier: 1 article (04/2015)|
|9.||Díez, Juana: 1 article (04/2015)|
|10.||Sanjuan, Xavier: 1 article (04/2015)|
|1.||Hypertension (High Blood Pressure)
11/01/1994 - "5. In conclusion, the present study could find no evidence to support a genetic association between the I/D polymorphism of DCP1 and blood pressure in a group with severe, familial hypertension living in Sydney."
04/01/1994 - "2. The study involved 35 Caucasian patients with severe, familial essential hypertension, who were not being treated with DCP1 inhibitors, and 94 normotensives. "
05/01/1993 - "2. Mathematical predictions based on DCP1 association data suggest that high sib-pair numbers may be needed to achieve statistical significance by this approach, although differences in the severity of hypertension in different study groups could account for the disparate findings. "
08/01/1993 - "4. All but one of the hypertensive subjects had at least one of the hypertension-associated alleles, and although subjects homozygous for both were three times more frequent in the hypertensive group, examination of the nine possible genotypes suggested that the INSR and DCP1 alleles are independent markers for hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)"
11/01/1983 - "Using the fluorimetric method, the activity of dipeptidyl-carboxypeptidase (DCP) was studied in 85 patients suffering from essential hypertension. "
|2.||Alzheimer Disease (Alzheimer's Disease)
03/01/2003 - "Further research is needed to elucidate any role that the DCP1 polymorphism may play in relation to Alzheimer's disease. "
05/08/2002 - "No association between DCP1 genotype and late-onset Alzheimer disease."
01/01/1999 - "Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease."
05/08/2002 - "In a study of 261 patients with Alzheimer disease (AD) and 306 cognitively normal control subjects from Germany, Switzerland, and Italy, we found no association between genotype counts or allelic frequencies of DCP1, the gene encoding angiotensin-converting enzyme. "
01/01/2005 - "An insertion/deletion (I/D) polymorphism of the DCP1 gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer's disease (AD), but ambiguous results have also been presented. "
|3.||Sarcoidosis (Schaumann Disease)
03/01/1984 - "This is noteworthy because angiotensin converting enzyme, a zinc-dipeptidyl carboxypeptidase with a mechanism of action similar to that of the metalloendopeptidase, has also been reported to be increased in the serum of patients with active sarcoidosis. "
12/01/1979 - "Angiotensin converting enzyme (ACE) (dipeptidyl carboxypeptidase; peptidyldipeptide hydrolase, EC 18.104.22.168) was localized in epithelioid and giant cells within ACE-rich sarcoidosis granulomas, but not control granulomas, by immunofluorescence by using a rabbit anti-human ACE immunoglobulin for localization and fluorescein-labeled goat anti-rabbit immunoglobulin for detection. "
11/01/1981 - "We have screened several neuroblastoma cell lines of rat and mouse origin and found at least three cell lines that contain renin (EC 22.214.171.124), angiotensin-converting enzyme (dipeptidyl carboxypeptidase; peptidyldipeptide hydrolase, EC 126.96.36.199), and angiotensins I and II. This finding was interpreted to indicate that in these cells angiotensin formation takes place by an intracellular mechanism, in contrast to the extracellular mechanism well known to occur in plasma. "
03/01/1990 - "The metabolism of angiotensin (Ang) peptides was studied in NG108-15 neuroblastoma x glioma hybrid cells which express Ang II receptors, renin, dipeptidyl carboxypeptidase A (converting enzyme), as well as Ang I and Ang II. In these experiments, 0.2 nM of either 125I-Ang I or 125I-Ang II was incubated with intact cell monolayers and the medium was analyzed for 125I-products by high performance liquid chromatography. "
11/01/2003 - "A dipeptidyl carboxypeptidase activity in the Dunning rat prostate tumor was characterized. "
12/01/1997 - "It is concluded that the Hip-Arg-Phe-cleaving enzyme in adrenomedullary tumor is probably identical to the purportedly novel dipeptidyl carboxypeptidase that we detected earlier in rabbit ear artery wall, which converts (Met5)-enkephalin-Arg6,Phe7 to (Met5)-enkephalin."
12/01/1997 - "Hip-Arg-Phe-, Hip-Phe-Arg- and Hip-His-Leu-cleaving dipeptidyl carboxypeptidase activities were measured in the supernatant (S2) and pellet (P2) fractions obtained by ultracentrifugation of human adrenal tumor preparations. "
|1.||Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
|2.||dipeptidyl carboxypeptidase (peptidyl-dipeptidase Dcp)
|9.||Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
|10.||LDL-Receptor Related Protein 1 (LDL-Receptor Related Protein)