|1.||Williams, David E: 5 articles (01/2012 - 03/2002)|
|2.||Krueger, Sharon K: 4 articles (01/2012 - 03/2002)|
|3.||Bennett, Brian J: 3 articles (01/2015 - 01/2013)|
|4.||Phillips, Ian R: 3 articles (01/2012 - 09/2003)|
|5.||Shephard, Elizabeth A: 3 articles (01/2012 - 09/2003)|
|6.||Cashman, John R: 3 articles (03/2009 - 04/2003)|
|7.||Brown, J Mark: 2 articles (10/2015 - 01/2015)|
|8.||Bulgakova, I V: 2 articles (10/2015 - 01/2012)|
|9.||Polonikov, A V: 2 articles (10/2015 - 01/2012)|
|10.||Lusis, Aldons J: 2 articles (01/2015 - 01/2013)|
|1.||Drug Toxicity (Drug Safety)
09/01/2003 - "FMO3 is also a drug-metabolizing enzyme and compromised activity is expected to have implications for the efficacy of drug treatment and the possibility of adverse drug reactions both in TMAuric patients and in the general population. "
12/01/2001 - "Statistically significant heterogeneity in the relative frequencies of single and multiple site alleles, haplotypes, and genotypes of the human FMO3 among ethnic subdivisions suggests that population differences in the susceptibility of humans to abnormal metabolism or adverse drug reactions for chemicals metabolized by human FMO3 could exist."
09/01/2000 - "With the recent observation of human FMO3 genetic polymorphism and poor metabolism phenotype in certain human populations, variant human FMO3 may contribute to adverse drug reactions or exaggerated clinical response to certain medications. "
01/01/2015 - "Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis."
01/01/2014 - "SNPs in or near Fmo3, Sele and Selp for Ath44, and Lbp and Pkig for Ath45 were suggested for further investigation as potential candidates underlying the atherosclerosis susceptibility."
10/01/2015 - "These recent studies show that inhibition of FMO3 stimulates macrophage reverse cholesterol transport and protects against atherosclerosis in mice. "
01/01/2015 - "We performed silencing and overexpression studies of flavin containing monooxygenase (FMO) 3 in hyperlipidemic mouse models to examine its effects on trimethylamine N-oxide (TMAO) levels and atherosclerosis. "
01/01/2015 - "FMO3 produces trimethylamine N-oxide (TMAO), which has recently been suggested to promote atherosclerosis in mice and humans. "
10/01/2011 - "For associations with clearance, 48 cancer patients treated in a phase I study were analyzed for ABCB1, ABCG2 and FMO3 polymorphisms. "
12/01/2006 - "Because SeMet has anti-cancer, chemopreventive, and toxic properties, the kinetic results suggest that FMO3 is likely to play a role in the biological activities of SeMet at low exposure conditions."
08/01/2006 - "The genotypes and allele frequencies of the MDR1/C3435T, FMO3/G488A, FMO3/A923G and CYP1A2/G-3860 A polymorphisms were not significantly different in cancer-free subjects and CRC patients. "
07/01/2002 - "6-methylhydroxylation of the anti-cancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by flavin-containing monooxygenase 3."
08/01/2006 - "We analyzed five single-nucleotide polymorphisms (SNP) in 93 cancer-free volunteers and 111 patients with CRC: one common genetic variant of the PGP-encoding MDR1 gene and four SNP in genes for metabolic enzymes (two SNP in FMO3 and two SNP in CYP1A2). "
05/25/2013 - "This is the first study conducted regarding the association of FMO3 Glu158Lys and Glu308Gly genetic polymorphisms and ischemic stroke risk in Turkish population."
05/25/2013 - "In this study, we aimed to investigate the relationship between FMO3 Glu158Lys and Glu308Gly variants, and the risk of incidence of ischemic stroke in Turkish population. "
05/25/2013 - "In the case-control analysis, no significant difference was observed between stroke patients and controls with respect to FMO3 Glu158Lys and Glu308Gly polymorphisms' genotype and allele frequency distribution. "
05/25/2013 - "Flavin containing monooxygenase 3 genetic polymorphisms Glu158Lys and Glu308Gly and their relation to ischemic stroke."
05/01/2012 - "[Association of rs10912745 and rs4916375 polymorphisms located in the cluster of flavin-containing monooxygenase genes, with ischaemic cardioembolic stroke]."
|5.||Hypertension (High Blood Pressure)
01/01/2014 - "This is the first study reporting the association of the FMO3 gene polymorphism and the risk of essential hypertension. "
01/01/2005 - "These results suggest that the variants in the FMO3 gene do not predispose to essential hypertension in this population."
01/01/2005 - "We investigated whether common polymorphisms of the FMO3 gene confer an increased risk for elevated blood pressure and/or essential hypertension. "
04/01/2003 - "Information as to whether variants of the flavin-containing monooxygenase form 3 contributes to hypertension and/or other diseases are presented. "
01/01/2014 - "The Flavin-Containing Monooxygenase 3 Gene and Essential Hypertension: The Joint Effect of Polymorphism E158K and Cigarette Smoking on Disease Susceptibility."
|1.||dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)
|2.||trimethyloxamine (trimethylamine N-oxide)
|3.||Cytochrome P-450 CYP1A2 (CYP1A2)
|5.||Mixed Function Oxygenases (Monooxygenases)