|1.||Newton, Roger S: 2 articles (08/2014 - 09/2013)|
|2.||Mendivil, Carlos O: 1 article (05/2015)|
|3.||Lemus, Hernán N: 1 article (05/2015)|
|4.||de Cógáin, Mitra R: 1 article (12/2014)|
|5.||Tosh, Pritish K: 1 article (12/2014)|
|6.||Krambeck, Amy E: 1 article (12/2014)|
|7.||Vrtiska, Terri J: 1 article (12/2014)|
|8.||Lieske, John C: 1 article (12/2014)|
|9.||Pinkosky, Stephen L: 1 article (08/2014)|
|10.||Filippov, Sergey: 1 article (08/2014)|
09/01/2003 - "It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. "
05/01/1977 - "The feasibility of treating obesity by metabolic regulation has been explored in this study by examining the effect of (--)-hydroxycitrate on three types of experimentally induced obesity in the rodent.(--)-Hydroxycitrate was utilized because it depressed fatty acid and cholesterol synthesis in vivo through its activity as a potent competitive inhibitor of APT citrate lyase. "
09/24/2013 - "Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial."
08/01/2014 - "LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase."
08/01/2014 - "Because adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase play central roles in regulating lipid and glucose metabolism, pharmacological modulation of these two enzymes could provide an important therapeutic alternative for statin-intolerant patients with hypercholesterolemia."
07/01/1986 - "The activities of NADP+-linked malate dehydrogenase, citrate lyase, acetyl-CoA carboxylase, and fatty acid synthetase, although lower in tumors than in normal glands, were not different in HD as compared to HI tumors. "
09/01/2010 - "In cancer cells, the tandem activation of the fatty acid biosynthetic enzymes adenosine triphosphate citrate lyase, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) leads to increased synthesis of SFA and their further conversion into MUFA by stearoyl-CoA desaturase (SCD) 1. The roles of adenosine triphosphate citrate lyase, ACC and FAS in the pathogenesis of cancer have been a subject of extensive investigation. "
|1.||Adenosine Triphosphate (ATP)
|2.||Protein Kinases (Protein Kinase)
|3.||Adenosine Monophosphate (AMP)
|8.||Acetyl Coenzyme A (Acetyl-CoA)
|9.||Citric Acid (Citrate)
|10.||Fatty Acid Synthetase Complex (Fatty Acid Synthase)