chondroitin 4-sulfotransferase

sulfation takes places at the 4-position of N-acetylgalactosamine residues of chondroitin; see also chondroitin 6-sulfotransferase (EC 2.8.2.17)

Also Known As:

chondroitin sulfotransferase; chondroitin sulphotransferase; chondroitinsulfate-sulfotransferase; glycosaminoglycan sulfotransferase

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Sulfur Group Transferases
      - Sulfotransferases: 442
        chondroitin 4-sulfotransferase: 5

Experts

1.	Chang, Ling-Chu: 1 article (11/2019)
2.	Chen, Chih-Jung: 1 article (11/2019)
3.	Cheng, Wei-Chung: 1 article (11/2019)
4.	Hsieh-Wilson, Linda C: 1 article (11/2019)
5.	Hung, Yu: 1 article (11/2019)
6.	Jan, Chia-Ing: 1 article (11/2019)
7.	Lin, Pei-Le: 1 article (11/2019)
8.	Liu, Liang-Chih: 1 article (11/2019)
9.	Liu, Shu-Hsuan: 1 article (11/2019)
10.	Qi, Xiaoyang: 1 article (11/2019)

Related Diseases

1.	Spinal Cord Injuries (Spinal Cord Injury) 08/15/2007 - "While many different CSPGs are expressed after spinal cord injury (SCI) they all rely on the same enzymes, xylosyltransferase-I and -II (XT-I, XT-II) and chondroitin 4-sulfotransferase (C4ST) to add the repulsive chondroitin sulfate side chains to their core proteins. "
2.	Malaria 10/01/2010 - "Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria."
3.	Chondrosarcoma 01/22/1999 - "Purification and characterization of chondroitin 4-sulfotransferase from the culture medium of a rat chondrosarcoma cell line." 01/22/1999 - "Chondroitin 4-sulfotransferase, which transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate to position 4 of N-acetylgalactosamine in chondroitin, was purified 1900-fold to apparent homogeneity with 6.1% yield from the serum-free culture medium of rat chondrosarcoma cells by affinity chromatography on heparin-Sepharose CL-6B, Matrex gel red A-agarose, 3',5'-ADP-agarose, and the second heparin-Sepharose CL-6B. "
4.	Breast Neoplasms (Breast Cancer) 11/01/2019 - "Here we identify the chondroitin sulfotransferase CHST15 (GalNAc4S-6ST) as a novel HOX transcript antisense intergenic RNA (HOTAIR) target gene using RNA profiling and show that CHST15 is required for HOTAIR-mediated invasiveness in breast cancer cells. " 11/01/2019 - "Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15."
5.	Traumatic Brain Injuries (Traumatic Brain Injury) 08/01/2015 - "Decline in arylsulfatase B and Increase in chondroitin 4-sulfotransferase combine to increase chondroitin 4-sulfate in traumatic brain injury."

Related Drugs and Biologics

1.	Chondroitin Sulfates (Chondroitin Sulfate)
2.	Long Noncoding RNA
3.	N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)
4.	Sulfates (Sulfates, Inorganic)
5.	Sepharose (Agarose)
6.	RNA (Ribonucleic Acid)
7.	Proteins (Proteins, Gene)
8.	Enzymes
9.	Chondroitin
10.	Acetylgalactosamine