|1.||Larrinaga, Gorka: 4 articles (01/2015 - 02/2007)|
|2.||Sanz, Begoña: 3 articles (01/2015 - 11/2011)|
|3.||Perez, Itxaro: 3 articles (01/2015 - 11/2011)|
|4.||Blanco, Lorena: 3 articles (01/2015 - 02/2007)|
|5.||López, José I: 3 articles (01/2015 - 02/2007)|
|6.||Mayas, María Dolores: 3 articles (09/2012 - 10/2011)|
|7.||Ramírez-Expósito, María Jesús: 3 articles (09/2012 - 10/2011)|
|8.||Martínez-Martos, José Manuel: 3 articles (09/2012 - 10/2011)|
|9.||Gil, Javier: 2 articles (01/2015 - 02/2007)|
|10.||Beitia, Maider: 2 articles (01/2015 - 01/2013)|
02/01/2007 - "Aminopeptidase B activity of the particulate fraction in tumors decreases (t = 2,399 vs. n = 13,536 UP/mg protein; P < 0.001) compared with nontumor tissues, and aspartyl-aminopeptidase activity decreases significantly in CCRCC (t = 137 vs. n = 223 UP/mg protein; P < 0.05). "
10/01/1978 - "When cultured mouse fibroblast strain C3H2K and rat fibroblast strain 3Y1 cells were transformed by SV40 or by a ts A mutant and maintained at permissive temperature, aminopeptidase A activity was drastically decreased, and the ratio of aminopeptidase A to aminopeptidase B was reduced to the levels of tumor cells. "
01/01/1984 - "Bestatin is an inhibitor of leucine aminopeptidase and aminopeptidase B which potentiates various immune functions, such as delayed hypersensitivity and antibody formation, and inhibits tumor cell growth in animal models. "
01/01/1978 - "Bestatin, which inhibited aminopeptidase B and leucine aminopeptidase, enhanced delayed-type hypersensitivity in a wide range of its low dosis (0.1-100 micrometer/mouse) and produced an immune resistance to the second inoculation of the same tumor cells. "
01/01/2015 - "The activity and mRNA levels of puromycin-sensitive aminopeptidase (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) were measured by fluorimetric and quantitative RT-PCR methods in colorectal mucosa and tumor tissues and plasma samples from CRC patients (n=81). "
01/01/2010 - "Various physiological functions of Bestatin have been identified, viz.: (1) an immunomodifier for enhancing the proliferation of normal human bone marrow granulocyte-macrophage progenitor cells to form CFU-GM colonies; Bestatin exerts a direct stimulating effect on lymphocytes via its fixation on the cell surface and an indirect effect on monocytes via aminopeptidase B inhibition of tuftsin catabolism; (2) an immunorestorator and curative or preventive agent for spontaneous tumor; Bestatin alone or its combination with chemicals can prolongate the disease-free interval and survival period in adult acute or chronic leukemia, therefore, it was primarily marketed in 1987 in Japan as an anticancer drug and servers as the only marketed inhibitor of Aminopeptidase N (APN/CD13) to cure leukemia to date; (3) a pan-hematopoietic stimulator and restorator; Bestatin promotes granulocytopoiesis and thrombocytopoiesis in vitro and restores them in myelo-hypoplastic men; (4) an inhibitor of several natural opioid peptides. "
|3.||Breast Neoplasms (Breast Cancer)
10/01/2011 - "We observed an increase in aminopeptidase N (APN) and aminopeptidase B (APB) activities in women with breast cancer; however, a decrease in aspartyl-aminopeptidase (AspAP) activity in premenopausal women. "
03/01/2006 - "Aminopeptidase N (APN), aminopeptidase B (APB) and aminopeptidase A (aspartyl- and glutamyl-aminopeptidase, APA) activities are measured in the pineal gland of rats with breast cancer induced by N-methyl nitrosourea (NMU). "
05/01/2012 - "The aim of this study was to investigate the putative changes in serum angiotensinase activities (aminopeptidase N, APN; aminopeptidase B, APB; aminopeptidase A, APA; aspartyl aminopeptidase, ASAP) involved in the renin-angiotensin system (RAS) in women with breast cancer treated or not with a neoadjuvant therapy of paclitaxel and anthracycline and in healthy women volunteers. "
12/27/1973 - "Evidence on the involvement in inflammation of an enzyme resembling aminopeptidase B."
01/01/1982 - "This histochemical study showed that experimentally arteriosclerotic rats, subjected to an occlusal stress of six weeks' duration, showed an inflammation-related increase of chloride-activated arginine aminopeptidase and acid phosphatase activity in the basal cells of the gingival epithelium. "
01/01/1982 - "The activity of chloride-activated arginine aminopeptidase and acid and alkaline phosphatase in the gingival connective tissue was slight and suggestive of chronic inflammation. "
|5.||Hypertension (High Blood Pressure)
11/01/1986 - "Inhibitors of aminopeptidase B suppress the development of hypertension in spontaneously hypertensive rats."
05/01/1998 - "To analyze the aminopeptidase response to the specific conditions of the reduced renal mass saline model of arterial hypertension, aminopeptidase A activity (glutamyl- and aspartyl-aminopeptidase), aminopeptidase M activity (alanyl-aminopeptidase), aminopeptidase B activity (arginyl-aminopeptidase), pyroglutamyl-aminopeptidase and cystinyl-aminopeptidase were measured in the neurohypophysis, in the adrenal gland and in serum of this model of hypertension. "
01/01/2013 - "In the present work we studied the activity of several proteolytic regulatory enzymes related to renin-angiotensin-system (RAS) (aminopeptidase A, APA; aminopeptidase N, APN; aminopeptidase B, APB; and insulin-regulated aminopeptidase, IRAP); with oxytocin regulation (oxytocinase); with the metabolism of GnRH and TRH (pyrrolidone carboxypeptidase, Pcp); and with enkephalins metabolism (enkephalindegrading activity, EDA), to elucidate their role in the mechanisms responsible of essential hypertension and to discuss the possible gender differences. "
|1.||CD13 Antigens (Alanine Aminopeptidase)
|3.||Opioid Peptides (Opioid Peptide)
|5.||Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)
|9.||Leucyl Aminopeptidase (S, Peptidase)