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aminoacyl-histidine dipeptidase

Also Known As:
carnosinase; homocarnosinase
Networked: 56 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Janssen, Bart: 6 articles (08/2010 - 08/2005)
2. Peters, Verena: 5 articles (11/2015 - 08/2005)
3. Zschocke, Johannes: 4 articles (11/2015 - 08/2005)
4. Aldini, Giancarlo: 4 articles (02/2014 - 06/2006)
5. Babizhayev, Mark A: 4 articles (01/2013 - 01/2009)
6. Yard, Benito A: 4 articles (08/2010 - 08/2005)
7. Bakker, Stephan J L: 4 articles (08/2010 - 08/2005)
8. van der Woude, Fokko J: 4 articles (08/2010 - 08/2005)
9. Freedman, Barry I: 4 articles (08/2009 - 03/2007)
10. Baelde, Hans: 3 articles (10/2015 - 08/2005)

Related Diseases

1. Chronic Disease (Chronic Diseases)
2. Inflammation
3. Diabetic Nephropathies (Diabetic Nephropathy)
4. Hyperglycemia
10/01/2015 - "Therefore, this study investigates whether exercise training and the consequent reduction in hyperglycemia can suppress carnosinase activity and content in adults with type 2 diabetes. "
10/01/2015 - "On the one hand, animal and human data suggest that hyperglycemia increases plasma carnosinase activity. "
08/01/2010 - "N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia."
11/01/2003 - "In this experiment, the following results were observed in rats: (i) A certain amount (0.01% or 0.001%) but not a larger amount (0.1%) of L-carnosine given as a diet suppressed the hyperglycemia induced by LCV-injection of 2DG (2DG-hyperglycemia); (ii) LCV-injection but not the injection into the intraperitoneal space (IP) of a certain amount of L-histidine suppressed the 2DG-hyperglycemia; (iii) treatments of diphenhydramine, an H1 antagonist, and alpha-fluoromethylhistidine, an inhibitor of histamine-synthesizing enzyme, reduced the 2DG-hyperglycemia; (iv) the plasma L-carnosine concentration and carnosinase activity showed daily changes; (v) the plasma L-carnosine concentration was significantly lower in the streptozotocin-diabetic rats; (vi) exercise by a running wheel tended to increase carnosine synthase activity in the gastrocnemius muscle and elevated the plasma L-carnosine concentration in the dark (active) period, and enhanced the plasma carnosinase activity in the light period; (vii) IP-injection of certain amount of L-carnosine stimulated the feeding response to IP-injection of 2DG. "
5. Kidney Diseases (Kidney Disease)

Related Drugs and Biologics

1. Dipeptides
2. Histidine (L-Histidine)
3. Carnosine
4. N-acetylcarnosine
5. Ophthalmic Solutions (Eye Drops)
6. carcinine
7. Leucine (L-Leucine)
8. Oxygen
9. Creatine Kinase (Creatine Phosphokinase)
10. Anserine

Related Therapies and Procedures

1. Therapeutics
2. Coronary Artery Bypass (Coronary Artery Bypass Surgery)