alkylglycerone-phosphate synthase

replaces the acyl moiety of acylDHAP with a long chain fatty alcohol; intact alcohol including the oxygen atom is incorporated into alkyl-DHAP

Also Known As:

ADAPAT; ADHPS; acylglycerone-3-phosphate-long chain-alcohol O-3-phospho-2-oxopropanyl transferase; alkyl-DHAP synthase; alkyl-dihydroxyacetone phosphate synthase; alkyldihydroxyacetone phosphate acyltransferase; alkyldihydroxyacetone phosphate synthetase; alkyldihydroxyacetonephosphate synthase

Networked: 23 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Alkyl and Aryl Transferases: 180
      - alkylglycerone-phosphate synthase: 23

Experts

1.	Zhu, Yu: 9 articles (01/2021 - 07/2014)
2.	Yang, Ping: 3 articles (05/2015 - 07/2014)
3.	Zhang, Ling: 3 articles (05/2015 - 07/2014)
4.	Qian, Liyu: 2 articles (10/2020 - 01/2018)
5.	He, Lu: 2 articles (05/2018 - 03/2018)
6.	Yang, Bing: 2 articles (05/2018 - 03/2018)
7.	Xue, Jing: 2 articles (05/2015 - 01/2015)
8.	Andrés-Benito, Pol: 1 article (01/2021)
9.	Ayala, Victòria: 1 article (01/2021)
10.	Boada, Jordi: 1 article (01/2021)

Related Diseases

1.	Peroxisomal Disorders (Peroxisomal Disorder) 12/01/1999 - "To determine the turnover of alkyl-DHAP synthase in several peroxisomal disorders, pulse-chase experiments were performed. " 05/01/1999 - "Immunological analyses of alkyl-dihydroxyacetone-phosphate synthase in human peroxisomal disorders." 06/01/2007 - "Rhizomelic chondrodysplasia punctata type 3 is a severe peroxisomal disorder caused by inborn deficiency of alkyldihydroxyacetonephosphate synthase (ADPS). " 07/15/1997 - "Immunological localization and tissue distribution of alkyldihydroxyacetonephosphate synthase and deficiency of the enzyme in peroxisomal disorders." 05/01/1999 - "Collectively, these results visualize the peroxisomal localization of alkyl-DHAP synthase, indicate that the enzyme is unstable outside its target organelle and explain that normal enzyme protein levels found in some peroxisomal disorders result from protection against cytoplasmic degradation through import into peroxisomes. "
2.	Thyroid Neoplasms (Thyroid Cancer) 05/01/2018 - "In our previous study, a positive correlation between the expression of alkylglycerone phosphate synthase (AGPS) and the malignant phenotype of thyroid cancer cell lines was identified. " 05/01/2018 - "Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO."
3.	Zellweger Syndrome (Zellweger's Syndrome) 07/01/1985 - "Alkyl dihydroxyacetone phosphate synthase in human fibroblasts and its deficiency in Zellweger syndrome." 04/01/2012 - "Here, we report that GPI lipid remodeling is defective in cells from patients with Zellweger syndrome having mutations in the peroxisomal biogenesis factors PEX5, PEX16, and PEX19 and in cells from patients with RCDP types 1, 2, and 3 caused by mutations in PEX7, DHAP-AT, and alkyl-DHAP synthase, respectively. " 05/01/1987 - "Dihydroxyacetone phosphate acyltransferase (EC 2.3.1.42) and alkyl dihydroxyacetone phosphate synthase (EC 2.5.1.26) have altered activity and kinetic constants in homogenates from Zellweger syndrome fibroblasts. " 12/01/1999 - "In Zellweger syndrome and rhizomelic chondrodysplasia punctata fibroblast cell lines, in which alkyl-DHAP synthase cannot be imported into peroxisomes, the enzyme was mainly detected in its precursor form. " 05/01/1999 - "In Zellweger syndrome and rhizomelic chondrodysplasia punctata fibroblast cell lines, alkyl-DHAP synthase protein levels on immunoblots were strongly decreased and residual immunofluorescence was diffusely localized throughout the cytoplasm. "
4.	Neoplasms (Cancer) 05/01/2015 - "Finally, we optimized the BITC construction targeting alkylglycerone phosphate synthase (AGPS) by computer-aided design, and the derivants also showed anti-tumor potential in vitro." 07/01/2014 - "Accumulating evidence suggests that the alkylglycerone phosphate synthase (AGPS) is involved in the suppression of some types of tumor. " 01/01/2015 - "Lipids metabolism was involved in the process of many types of tumor and alkylglycerone phosphate synthase (AGPS) was considered implicated in tumor process. " 06/01/2018 - "The downregulated expression of Tudor-staphylococcal nuclease (SN) and alkylglycerone phosphate synthase (AGPS) can decrease cancer malignancy, and the overexpression of them can the increase viability and migration potential of various tumor cell types; however, the role of AGPS in the proliferation and migration of glioma, and the association of Tudor-SN and AGPS in human glioma is not clear. " 03/01/2018 - "Computer-aided design of temozolomide derivatives based on alkylglycerone phosphate synthase structure with isothiocyanate and their pharmacokinetic/toxicity prediction and anti-tumor activity in vitro."
5.	Glioma (Gliomas) 10/01/2020 - "Effect of alkylglycerone phosphate synthase on the expression levels of lncRNAs in glioma cells and its functional prediction." 07/01/2014 - "Role and mechanism of the alkylglycerone phosphate synthase in suppressing the invasion potential of human glioma and hepatic carcinoma cells in vitro." 06/01/2018 - "Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-κB and microRNA-127 in human glioma U87MG cells." 05/01/2015 - "The effect of benzyl isothiocyanate and its computer-aided design derivants targeting alkylglycerone phosphate synthase on the inhibition of human glioma U87MG cell line." 06/01/2018 - "The downregulated expression of Tudor-staphylococcal nuclease (SN) and alkylglycerone phosphate synthase (AGPS) can decrease cancer malignancy, and the overexpression of them can the increase viability and migration potential of various tumor cell types; however, the role of AGPS in the proliferation and migration of glioma, and the association of Tudor-SN and AGPS in human glioma is not clear. "

Related Drugs and Biologics

1.	Enzymes
2.	Proteins (Proteins, Gene)
3.	Ether (Diethyl Ether)
4.	Lipids
5.	Plasmalogens
6.	Esters
7.	Catalase
8.	glycerone-phosphate O-acyltransferase
9.	Acyl-CoA Oxidase
10.	Octoxynol (Triton X 100)