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heparosan N-sulfate D-glucuronosyl 5-epimerase

converts D-glucuronic acid to L-iduronic at the polymer level during synthesis of heparin

Also Known As:

D-glucuronyl C-5 epimerase; uronosyl C-5 epimerase

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Isomerases: 463
    - Racemases and Epimerases: 412
      - Carbohydrate Epimerases
        heparosan N-sulfate D-glucuronosyl 5-epimerase: 2

Related Diseases

1.

05/10/1980 - "Heparosan N-sulfate D-glucuronosyl 5-epimerase, which catalyzes the conversion of beta-D-glucuronosyl to alpha-L-iduronosyl residues in the course of heparin biosynthesis, has been purified approximately 9000-fold from the high speed supernatant fraction of a homogenate of a mouse mastocytoma. "
01/25/1984 - "The substrate specificity of heparosan N-sulfate D-glucuronosyl 5-epimerase from a mouse mastocytoma was examined to determine the effects of N-acetyl and O-sulfate groups on substrate recognition by the enzyme. "

Related Drugs and Biologics

1.	Sulfates (Sulfates, Inorganic)
2.	Heparin (Liquaemin)
3.	Enzymes