mecobalamin (methylcobalamin)

RN given refers to parent cpd

Also Known As:

methylcobalamin; CH3-B12; mecobalamin monohydrate; mecobalamin, (13beta)-isomer; mecobalamin, 3H-labeled; mecobalamin, 57Co-labeled; mecobalamin, Co-methyl-13C-labeled; mecobalamin, Co-methyl-14C-labeled; methylcobalamine; methylvitamin B12; cobinamide, Co-methyl deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole

Networked: 277 relevant articles (51 outcomes, 61 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kaji, Ryuji: 6 articles (01/2022 - 01/2014)
2.	Spence, J David: 6 articles (01/2022 - 02/2016)
3.	Kuwabara, Satoshi: 4 articles (01/2022 - 01/2014)
4.	Tanaka, Hiroyuki: 4 articles (02/2020 - 09/2013)
5.	Hankey, Graeme J: 3 articles (01/2022 - 01/2017)
6.	Ikeda, Ken: 3 articles (01/2022 - 07/2015)
7.	Isose, Sagiri: 3 articles (01/2022 - 01/2014)
8.	Izumi, Yuishin: 3 articles (01/2022 - 12/2018)
9.	Oki, Ryosuke: 3 articles (01/2022 - 12/2018)
10.	Rosenblatt, David S: 3 articles (01/2022 - 07/2002)

Related Diseases

1.	Peripheral Nervous System Diseases (PNS Diseases) 01/01/2014 - "Safety and efficacy of intravenous ultra-high dose methylcobalamin treatment for peripheral neuropathy: a phase I/II open label clinical trial." 06/01/2008 - "However, more precise, double-blind and randomised control studies are necessary to confirm the efficacy of mecobalamin on hyperhomocysteinaemia, peripheral neuropathy interaction, and cardiovascular, neurological and osteoporotic mortality or morbidity." 12/01/2020 - "Conclusion: Our findings indicate that mecobalamin in combination may be effective in improving clinical therapeutic efficacy and NCV outcomes for peripheral neuropathy patients, but the evidence is not clear for mecobalamin alone. " 04/01/2015 - "Methylcobalamine is effective in peripheral neuropathies." 04/01/2015 - "Response to: 'Methylcobalamine is effective in peripheral neuropathies'."
2.	Pain (Aches) 11/01/2020 - "This study indicates that local injection of methylcobalamin produces significant pain relief from SOHN and is superior to systemic administration." 12/01/2011 - "There was a significant improvement in the Oswestry Disability Index and Visual Analogue Scale pain scores in the methylcobalamin group as compared with the placebo group (p-value less than 0.05). " 12/01/2020 - "The clinical therapeutic efficacy, pain score, neuropathic symptom score, nerve conduction velocities (NCVs), and adverse events of mecobalamin were assessed and were pooled by using a random-effects model. " 01/27/2021 - "The treatment of patients with DN with 1 mg of oral methylcobalamin for twelve months increased plasma B12 levels and improved all neurophysiological parameters, sudomotor function, pain score, and QoL, but it did not improve CARTS and MNSIE." 01/01/2019 - " fourth included study compared ALC with methylcobalamin, but did not report effects on pain. "
3.	Neuralgia (Stump Neuralgia) 11/01/2020 - "A single-center randomized controlled study was conducted to evaluate the efficacy of local methylcobalamin injection for subacute ophthalmic herpetic neuralgia (SOHN). " 01/01/2023 - "Acupuncture plus methylcobalamin showed more favorable effects than methylcobalamin alone in relieving neuralgia, restoring nerve conduction velocity and improving quality of life. " 11/01/2020 - "Local Administration of Methylcobalamin for Subacute Ophthalmic Herpetic Neuralgia: A Randomized, Phase III Clinical Trial." 01/01/2016 - "Methylcobalamin attenuated vincrinstine-induced neuropathic pain, which was accompanied by inhibition of intraepidermal nerve fibers loss and mitochondria impairment. " 06/01/2013 - "A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia."
4.	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 01/01/2017 - "Methylcobalamin in Vitamin B12 Deficiency: To Give or not to Give?" 01/01/2015 - "Treatment of vitamin B12 deficiency-methylcobalamine? " 12/01/2017 - "Efficacy of oral methylcobalamin in treatment of vitamin B12 deficiency anemia in children." 11/15/2023 - "To evaluate the efficacy and safety of sublingual methylcobalamin for the treatment of vitamin B12 deficiency anemia in children. " 11/15/2023 - "Therapeutic Response to Sublingual Methylcobalamin in Children With Vitamin B12 Deficiency Anemia."
5.	Diabetic Neuropathies (Diabetic Neuropathy) 01/01/1987 - "These findings suggest that a high concentration of methylcobalamin in spinal fluid is highly effective and safe for treating the symptoms of diabetic neuropathy." 01/01/1999 - "Mecobalamin might be worthy of use as a safe agent in the treatment of diabetic neuropathies." 01/01/1999 - "To investigate the effect of mecobalamin on diabetic neuropathies. " 01/01/1999 - "[Effect of mecobalamin on diabetic neuropathies. " 01/01/1995 - "Effect of methylcobalamin on diabetic autonomic neuropathy as assessed by power spectral analysis of heart rate variations."

Related Drugs and Biologics

1.	Vitamin B 12 (Cyanocobalamin)
2.	NAD (NADH)
3.	Tablets
4.	Lidocaine (Xylocaine)
5.	Pregabalin (Lyrica)
6.	Vitamin E
7.	Thioctic Acid (Lipoic Acid)
8.	Thiamine (Aneurin)
9.	mecobalamin (methylcobalamin)
10.	5-methyltetrahydrofolate

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Intramuscular Injections
4.	Drug Therapy (Chemotherapy)
5.	Conservative Treatment