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isogabaculine
irreversible enzyme-activated inhibitor of GABA-transaminase; RN given refers to parent cpd without isomeric designation
Also Known As:
3-aminocyclohex-1,5-dienylcarboxylic acid; isogabaculine trifluoromesylate; isogabaculine trifluoromesylate, (-)-isomer; 1,5-Cyclohexadiene-1-carboxylic acid, 3-amino-
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Alicyclic Hydrocarbons: 1
Cycloparaffins: 6
Cyclohexanes: 3
Cyclohexenes: 4
isogabaculine: 1
Cyclohexanecarboxylic Acids
isogabaculine: 1
Carboxylic Acids: 973
Carbocyclic Acids
Cyclohexanecarboxylic Acids
isogabaculine: 1
Related Diseases
1.
Neuroblastoma
07/01/1982 - "
As determined by half-life measurements of ODC and intracellular GABA concentrations, isogabaculine apparently has a direct stabilizing effect on ODC in neuroblastoma cells that is unrelated to the accumulation of GABA due to GABA transaminase inhibition.
"
07/01/1982 - "
Putrescine metabolism to GABA or spermidine was determined in C6, HTC, and neuroblastoma cells in the presence or absence of isogabaculine and/or GABA.
"
07/01/1982 - "
Neither GABA nor isogabaculine treatment dramatically altered the metabolism of putrescine to GABA or spermidine in neuroblastoma, C6 glioma, or HTC cells.
"
07/01/1982 - "
Isogabaculine (3-amino-1,3-cyclohexadienyl carboxylic acid; RMI 71,932), an irreversible inhibitor of GABA transaminase, when added to mouse neuroblastoma cells in spinner culture at the time of induction of cell proliferation, increased ornithine decarboxylase (ODC) activity threefold above that of normal control cells and twofold above that of GABA (gamma-aminobutyric acid)-treated cells.
"
2.
Hepatocellular Carcinoma (Hepatoma)
07/01/1982 - "
Isogabaculine did not affect ODC activity of rat glioma (C6) or rat hepatoma (HTC) cells.
"
3.
Glioma (Gliomas)
07/01/1982 - "
Isogabaculine did not affect ODC activity of rat glioma (C6) or rat hepatoma (HTC) cells.
"
07/01/1982 - "
Neither GABA nor isogabaculine treatment dramatically altered the metabolism of putrescine to GABA or spermidine in neuroblastoma, C6 glioma, or HTC cells.
"
Related Drugs and Biologics
1.
Spermidine
2.
Putrescine
3.
Ornithine Decarboxylase (Decarboxylase, Ornithine)
4.
gamma-Aminobutyric Acid (GABA)
5.
Carboxylic Acids
6.
4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)