2-Acetylaminofluorene

A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

Also Known As:

2 Acetylaminofluorene; 2-AAF; 2-Fluorenylacetamide; AAF, Aminofluorene; Acetylaminofluorene; N-2-Fluorenylacetamide; N-Acetyl-2-Aminofluorene; 2 Acetamidofluorene; 2 Fluorenylacetamide; Aminofluorene AAF; Fluoren 2 ylacetamide; N 2 Fluorenylacetamide; N Acetyl 2 Aminofluorene; 2-Acetamidofluorene; Fluoren-2-ylacetamide; Acetamide, N-9H-fluoren-2-yl-

Pharmalogical Action Categories:

Carcinogens

Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - 2-Acetylaminofluorene: 525
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Fluorenes: 7
        2-Acetylaminofluorene: 525
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Acetamides: 21
        2-Acetylaminofluorene: 525
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Fluorenes: 7
    - 2-Acetylaminofluorene: 525

7-iodo-N-hydroxy-N-2-acetylaminofluorene

Bio-Agent Context: Research Results