HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

coenzyme A-glutathione mixed disulfide

Also Known As:

CoASSG; coenzyme A glutathione disulfide; glutathione-CoA mixed disulfide

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Liang, Li-Ping: 1 article (12/2010)
2.	Patel, Manisha: 1 article (12/2010)
3.	Waldbaum, Simon: 1 article (12/2010)
4.	Dugas, Tammy R: 1 article (08/2003)
5.	Kanz, Mary F: 1 article (08/2003)
6.	Liu, Hanlin: 1 article (08/2003)
7.	Santa Cruz, Vicente: 1 article (08/2003)
8.	Kelley, Donald K: 1 article (03/2002)
9.	O'Donovan, Donough J: 1 article (03/2002)
10.	Ramsay, Patricia L: 1 article (03/2002)

Related Diseases

1.	Lung Injury 09/15/2001 - "In the present studies, we exposed adult male C57/Bl6 mice to >95% O2 for up to 72 h and obtained lung and liver samples for assessment of lung injury, measurements of tissue concentrations of coenzyme A (CoASH) and the corresponding mixed disulfide with glutathione (CoASSG), as possible biomarkers of intramitochondrial thiol redox status. "
2.	Edema (Dropsy) 08/01/2003 - "Treatment of rats with a minimally hepatotoxic dose of DAPM (without GSx depletion) produced at 6 h injury similar to previous studies: moderate oncosis of biliary epithelial cells (BEC), mild edema of portal triads, and increases in glutathione S-transferase (GST) activities without alterations in hepatic GSx/glutathione disulfide (GSSG), coenzyme A (CoASH)/coenzyme A-glutathione disulfide (CoASSG), or thiobarbituric acid-reactive substances (TBARS). "
3.	Hyperoxia 03/01/2002 - "Lung tissue concentrations of CoASSG in the Fischer-344 rats declined from 0.89 +/- 0.15 to 0.51 +/- 0.13 nmol/g of lung after 48 h of hyperoxia. " 09/15/2001 - "Interestingly, CoASSG concentrations increased (from 6.72+/-0.54 to 14.10+/-1.10 nmol/g of liver in air-breathing controls and 72 h of hyperoxia, respectively, P<0.05), and CoASH/CoASSG ratios decreased in the livers of mice exposed to hyperoxia. " 03/01/2002 - "CoASH/CoASSG ratios were lower in animals exposed to hyperoxia, satisfying our previously defined criteria for an oxidant stress on this thiol/disulfide redox couple, but absolute CoASSG levels were not increased, as would be expected for oxidant stresses driven simply by increases in reactive oxygen species or other oxidants. "
4.	Starvation 07/01/1978 - "The pool of coenzyme A--glutathione mixed disulfide (CoASSG) rapidly increased 2.0 times in response to oxygen starvation and 1.5 times in response to glucose starvation but did not change following ammonia starvation. "
5.	Epilepsy (Aura) 12/01/2010 - "Tissue levels of GSH, GSH/GSSG, coenzyme A (CoASH), and CoASH/CoASSG were persistently impaired at all measured time points throughout epileptogenesis, that is, acutely (24-48h), during the 'latent period' (48h to 7days), and chronic epilepsy (21days to 3months). "

Related Drugs and Biologics

1.	Coenzyme A (CoA)
2.	coenzyme A-glutathione mixed disulfide
3.	Glutathione Disulfide (GSSG)
4.	Sulfhydryl Compounds (Thiols)
5.	Disulfides
6.	Thiobarbituric Acid Reactive Substances
7.	Biomarkers (Surrogate Marker)
8.	Glutathione Transferase (Glutathione S-Transferase)
9.	Glutathione (Reduced Glutathione)
10.	DAPM