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oxamethacin
structure
Also Known As:
1-(4-chlorobenzoyl)-methyl-5-methoxy-3-indolylacetohydroxamic acid; Flogar; oxametacine; 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-N-hydroxy-5-methoxy-2-methyl-
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indomethacin: 9574
oxamethacin: 5
Related Diseases
1.
Hyperthyroidism
05/01/1980 - "
Treatment with oxametacine, indomethacin, phenylbutazone, flufenamic acid and acetylsalicylic acid, increases the activity of hepatic TPO in hypothyroid state, whereas, in hyperthyroid rats, the same drugs are able to restore the normal enzymatic activity, except for acetylsalicylic acid.
"
03/30/1981 - "
In addition, the inhibitory effect of Indomethacin, Oxametacine and Phenylbutazone on PGE2 production is not affected by hyperthyroid state whereas hypothyroidism significantly limits the action of the mentioned non-steroid anti-inflammatory agents.
"
2.
Granuloma
06/01/1983 - "
In rats, dosed orally with 5 mg/kg [14C]-oxametacine, there is a 2.2-2.7 fold increase in radioactivity in the inflamed tissues, in the hind-paws of animals with adjuvant arthritis and in the granulomas of cotton-pellet implanted rats.
"
09/01/1981 - "
The anti-inflammatory activity of Indomethacin, Oxametacine and Phenylbutazone was evaluated in these animals using paw oedema provoked by carrageenan granulomas induced by cotton pellets and polyarthritis induced by Freund complete adjuvant.
"
3.
Pain (Aches)
01/01/1980 - "
When focusing on patients without associated drug therapy, 126/259 patients (50%) presented a good response on inflammation under oxamethacin and 98/236 patients (42%) a good response under indomethacin (p less than 10(-2)); 141/250 patients (56%) presented a good response on pain under oxamethacin and 117/236 (50%) under indomethacin (p less than 5.10(-2)).
"
4.
Inflammation (Inflammations)
01/01/1980 - "
When focusing on patients without associated drug therapy, 126/259 patients (50%) presented a good response on inflammation under oxamethacin and 98/236 patients (42%) a good response under indomethacin (p less than 10(-2)); 141/250 patients (56%) presented a good response on pain under oxamethacin and 117/236 (50%) under indomethacin (p less than 5.10(-2)).
"
5.
Hypothyroidism
03/30/1981 - "
In addition, the inhibitory effect of Indomethacin, Oxametacine and Phenylbutazone on PGE2 production is not affected by hyperthyroid state whereas hypothyroidism significantly limits the action of the mentioned non-steroid anti-inflammatory agents.
"
Related Drugs and Biologics
1.
Indomethacin (Indometacin)
2.
Phenylbutazone (Butazolidin)
3.
Dinoprostone (PGE2)
4.
Steroids
5.
Flufenamic Acid
6.
Carrageenan
7.
Aspirin (Acetylsalicylic Acid)
8.
Anti-Inflammatory Agents (Anti-Inflammatories)
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)