|1.||Jiang, Cheng: 7 articles (05/2010 - 07/2002)|
|2.||Lü, Junxuan: 7 articles (05/2010 - 07/2002)|
|3.||Zeng, Huawei: 6 articles (01/2015 - 06/2006)|
|4.||Wu, Min: 3 articles (01/2015 - 09/2009)|
|5.||Briske-Anderson, Mary: 3 articles (01/2012 - 06/2006)|
|6.||Hu, Hongbo: 3 articles (05/2010 - 07/2004)|
|7.||Chung, An-Sik: 3 articles (09/2008 - 04/2007)|
|8.||Kim, Aeyung: 3 articles (09/2008 - 04/2007)|
|9.||Wang, Zaisen: 3 articles (07/2004 - 07/2002)|
|10.||Dong, Yan: 2 articles (11/2013 - 05/2004)|
|1.||Prostatic Neoplasms (Prostate Cancer)
11/01/2013 - "Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer."
05/01/2004 - "This study addresses whether the putative active anticancer selenium metabolite methylselenol or its precursor methylseleninic acid (MSeA) specifically inhibits PSA expression in the androgen-responsive LNCaP prostate cancer cell model. "
07/01/2002 - "To test the hypothesis that methylselenol itself is responsible for exerting these cellular effects, we examined the apoptotic action on DU145 human prostate cancer cells and the G1 arrest effect on the human umbilical vein endothelial cells (HUVECs) of methylselenol generated with seleno-L-methionine as a substrate for L-methionine-alpha-deamino-gamma-mercaptomethane lyase (EC22.214.171.124, also known as methioninase). "
03/15/2012 - "In this regard, we investigated the efficacy of methylseleninic acid (MSeA), a penultimate precursor to the highly reactive selenium metabolite, methylselenol, to inhibit growth of invasive and hormone refractory rat (PAIII) and human (PC-3 and PC-3M) prostate cancer cells. "
10/01/2002 - "To explore potential molecular targets for mediating the chemopreventive activity, we contrasted the effects of methylseleninic acid (MSeA), a novel precursor of methylselenol, versus sodium selenite, a representative of the hydrogen selenide metabolite pool, on apoptosis execution, cell cycle distribution, and selected protein kinases in DU145 human prostate cancer cells. "
09/01/2009 - "In this study, we demonstrated that methylselenol exposure inhibited cell growth and we used a cancer signal pathway-specific array containing 15 different signal transduction pathways involved in oncogenesis to study the effect of methylselenol on cellular signaling. "
05/01/2013 - "When the MC26 cells were transplanted to their immune-competent Balb/c mice, methylselenol-treated MC26 cells had significantly less tumor growth potential than that of untreated MC26 cells. "
09/01/2009 - "However, little is known about the association between cancer signal pathways and methylselenol's inhibition of tumor cell invasion. "
06/01/2006 - "Furthermore, methylselenol inhibited the migration and invasion rate of the tumor cells by up to 53 and 76%, respectively, when compared with the control tumor cells. "
06/01/2006 - "To determine whether tumor cell migration, invasion, and cell cycle characteristics are inhibited by methylselenol, we exposed HT1080 cells to methylselenol. "
|3.||Colonic Neoplasms (Colon Cancer)
01/01/2010 - "In this study, we demonstrated that both DCA (75-300 micromol/l) and submicromolar methylselenol inhibited colon cancer cell proliferation by up to 64% and 63%, respectively. "
05/01/2013 - "Similar to our previous report on human HCT116 colon cancer cells, methylselenol also inhibited cell growth and led to an increase in G1 and G2 fractions with a concomitant drop in S-phase in mouse colon cancer MC26 cells. "
01/01/2010 - "In addition, DCA and methylselenol each increased colon cancer cell apoptosis rate by up to twofold. "
05/01/2013 - "Taken together, our data suggest that methylselenol modulates the expression of key genes related to cell cycle and apoptosis and inhibits colon cancer cell proliferation and tumor growth."
01/01/2012 - "In this study, the submicromolar concentrations of methylselenol were generated by incubating methionase with seleno-L methionine, and colon-cancer-derived HCT-116 cells and noncancerous colon NCM460 cells were exposed to methylselenol. "
|4.||Melanoma (Melanoma, Malignant)
09/01/2008 - "Long exposure of non-cytotoxic concentrations of methylselenol suppresses the invasive potential of B16F10 melanoma."
09/01/2008 - "To assess the inhibitory effects of methylselenol on the invasion of murine B16F10 melanoma cells, we carried out in vivo and in vitro experiments using Se-methylselenocysteine (Se-MSC) and selenomethionine (SeMet), respectively. "
08/01/2007 - "Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells."
08/01/2007 - "In this study, we examine the effects of methylselenol generated from selenomethionine (SeMet) by methioninase (METase) on cell proliferation, adhesion, and expression of integrins in murine melanoma B16F10 cells, which are metastatic in the lungs of syngeneic C57BL/6J mice. "
07/01/2002 - "Previous work based on mono-methyl selenium compounds that are putative precursors of methylselenol has strongly implicated this metabolite in the induction of caspase-mediated apoptosis of human prostate carcinoma and leukemia cells and G1 arrest in human vascular endothelial and cancer epithelial cells. "
07/01/2004 - "We and others have shown that selenite induces apoptotic DNA laddering in the p53-mutant DU145 prostate cancer cells and the p53-null HL60 leukemia cells without the cleavage of poly(ADP-ribose) polymerase (PARP; i.e., caspase-independent apoptosis), whereas selenium compounds leading to the formation of methylselenol induce caspase-mediated apoptosis in these cells. "
|7.||Sodium Selenite (Selenite)
|10.||DNA (Deoxyribonucleic Acid)
|3.||Heterologous Transplantation (Xenotransplantation)