carbetapentane (pentoxyverine)

RN given refers to parent cpd

Also Known As:

pentoxyverine; carbetapentane tannate; 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentyl-1-carboxylate; carbetapentane 1,5-napthalenedisulfonate (2:1); carbetapentane 2,6-napthalenedisulfonate (2:1); carbetapentane citrate; 1-phenylcyclopentanecarboxylic acid,2-(2-(diethylamino)ethoxy)ethyl ester

Networked: 18 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclopentanes: 58
        carbetapentane: 18

Experts

1.	Chen, Yu-Wen: 2 articles (08/2013 - 01/2012)
2.	Chu, Chin-Chen: 2 articles (08/2013 - 01/2012)
3.	Wang, Jhi-Joung: 2 articles (08/2013 - 01/2012)
4.	Abo Dena, Ahmed S: 1 article (01/2020)
5.	Ali, Alaa M: 1 article (01/2020)
6.	El-Sherbiny, Ibrahim M: 1 article (01/2020)
7.	Elfeky, Shaimaa A: 1 article (11/2019)
8.	Issa, Yousry M: 1 article (11/2019)
9.	Mohamed, Sabrein H: 1 article (11/2019)
10.	Kuo, Chang-Shin: 1 article (08/2013)

Related Diseases

1.	Seizures (Absence Seizure) 07/13/2001 - "Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation." 09/24/1986 - "The non-opioid antitussives dextromethorphan and carbetapentane, the active ingredients of several over-the-counter cough suppressants, provide a dose-related protection against maximal electroshock seizures in rats. " 06/01/1988 - "DM, carbetapentane, and caramiphen also are efficacious anticonvulsant agents in the rat maximal electroshock seizures test, and DM enhances the anticonvulsant effects of phenytoin (PHT). " 07/01/1989 - "Two antitussives, dextromethorphan and carbetapentane, which have been reported to bind to a common binding site in brain tissue and produce anticonvulsant effects in rats, were evaluated for their anticonvulsant effects against maximal electroshock-induced seizures, for their neurological impairing effects on the horizontal screen test, and their protective effects against N-methyl-D-aspartic acid (NMDA)-induced lethality in mice. "
2.	Catalepsy 05/01/2000 - "Thus, we performed a study to examine whether oxybutynin, pentoxyverine and etafenone, as well as propiverine, induce catalepsy in mice. " 05/01/2000 - "The intensity of drug-induced catalepsy was in the order: haloperidol > etafenone > pentoxyverine > propiverine > oxybutynin. "
3.	Cough 06/03/1988 - "For two weeks his mother had been taking pentoxyverine-containing cough drops for an upper respiratory tract infection. " 02/10/2012 - "Characterization of pentoxyverine metabolites in urine using GC/MS after intoxication with Silomat cough drops." 02/10/2012 - "The correlation of the results, the observed symptoms, and the access to the Silomat cough drops reveal an intoxication after ingestion of an unknown amount of the antitussive pentoxyverine. " 01/01/2004 - "2. Intraperitoneal (i.p.) administration of DEX (30 mg kg(-1)) and the sigma-1 agonists SKF-10,047 (1-5 mg kg(-1)), Pre-084 (5 mg kg(-1)), and carbetapentane (1-5 mg kg(-1)) inhibited citric-acid-induced cough in guinea-pigs. " 11/05/2019 - "Pentoxyverine citrate (PEN-citrate) is an antitussive (cough suppressant) drug used for cough associated with illnesses like common cold. "
4.	Ischemia 12/01/2006 - "DTG inhibition of ischemia-induced increases in [Ca(2+)](i) was mimicked by the sigma-1 receptor-selective agonists, carbetapentane, (+)-pentazocine and PRE-084 [2-(4-morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride], but not by the sigma-2-selective agonist, ibogaine, showing that activation of sigma-1 receptors is responsible for the effects. " 11/29/2002 - "The sigma receptor ligands (+)-N-allylnormetazocine ((+)-SKF10,047) and haloperidol, but not carbetapentane and R(+)-3-(3-hydroxyphenyl)-N-propylpiperidine ((+)-3-PPP), prevented chemical ischemia-induced neurotoxicity in a concentration-dependent manner. " 08/01/2006 - "Drugs that are known to inhibit cortical spreading depression (CSD), such as N-methyl-D-aspartate receptor antagonists MK-801 and 7-chlorokynurenic acid, and sigma-1 receptor agonists dextromethorphan and carbetapentane, did not reduce the frequency of PIDs, but did diminish the severity of episodic hypoperfusions, and prevented the expansion of severely hypoperfused cortex, thus improving CBF during 90 mins of acute focal ischemia. "
5.	Respiratory Tract Infections (Respiratory Tract Infection) 06/03/1988 - "For two weeks his mother had been taking pentoxyverine-containing cough drops for an upper respiratory tract infection. " 01/01/2020 - "Carbetapentane citrate, a non-opioid centrally-acting antitussive drug, is a common treatment for cough associated with other diseases such as common cold and respiratory tract infections. "

Related Drugs and Biologics

1.	Antitussive Agents (Antitussives)
2.	Dextromethorphan (Racemethorphan)
3.	Anticonvulsants (Antiepileptic Drugs)
4.	Opioid Analgesics (Opioids)
5.	N-Methylaspartate (NMDA)
6.	propiverine
7.	oxybutynin (Tavor)
8.	etafenone
9.	caramiphen
10.	Citric Acid (Citrate)

Related Therapies and Procedures

1.	Intravenous Infusions