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calophyllolid

structure

Also Known As:

calophyllolide; 5-methoxy-2,2-dimethyl-6-(2-methyl-1-oxo-2- butenyl)-10-phenyl-2H,8H-benzo(1,2-B':3,4-B')-dipyran-8-one

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        calophyllolid: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        calophyllolid: 2

Experts

1.	Cheng, Gui-fang: 1 article (10/2010)
2.	Liu, Gang: 1 article (10/2010)
3.	Ma, Tao: 1 article (10/2010)
4.	Wang, Lin: 1 article (10/2010)
5.	Furukawa, Hiroshi: 1 article (07/2006)
6.	Ito, Chihiro: 1 article (07/2006)
7.	Itoigawa, Masataka: 1 article (07/2006)
8.	Kaneda, Norio: 1 article (07/2006)
9.	Murata, Tomiyasu: 1 article (07/2006)
10.	Nakao, Keisuke: 1 article (07/2006)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 07/01/2006 - "In addition, the activity of caspase-9 and caspase-3 was also enhanced in a time-dependent manner upon treatment with the 4-substituted coumarins 2 and 3. Caspase-9 and caspase-3 inhibitors suppressed apoptosis induced by 4-substituted coumarins 2 and 3. These results suggest that calophyllolide (2) and mammea B/ BB (3) induced apoptosis in HL-60 cells through activation of the caspase-9/caspase-3 pathway, which is triggered by mitochondrial dysfunction."
2.	Edema (Dropsy) 10/01/2010 - "A new pyranocoumarin as an analogue of calophyllolide, compound 6, is firstly prepared and reported to have potent anti-inflammatory activity on carrageenin-induced edema in rats."

Related Drugs and Biologics

1.	Caspase 9
2.	Caspase 3 (Caspase-3)
3.	Coumarins
4.	Carrageenan