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2-tert-butylhydroquinone (tert-butylhydroquinone)

Also Known As:
tert-butylhydroquinone; TBHQ; 2-tertiary-butylhydroquinone; MTBHQ; mono-tert-butylhydroquinone; monotertiary butyl hydroquinone; 2-(1,1-dimethylethyl)-1,4-benzenediol
Networked: 87 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jin, Wei: 3 articles (01/2014 - 01/2010)
2. Jiang, Jian: 3 articles (01/2014 - 01/2010)
3. Wang, Handong: 3 articles (01/2014 - 01/2010)
4. Ni, Hongbin: 3 articles (01/2014 - 01/2010)
5. Liang, Weibang: 3 articles (01/2014 - 01/2010)
6. Li, Jiang: 3 articles (02/2005 - 01/2002)
7. Johnson, Jeffrey A: 3 articles (02/2004 - 01/2002)
8. Johnson, J A: 3 articles (06/2001 - 07/2000)
9. Li, Tao: 2 articles (09/2015 - 05/2014)
10. Lu, Xin-Yu: 2 articles (09/2015 - 05/2014)

Related Diseases

1. Brain Injuries (Brain Injury)
2. Neoplasms (Cancer)
04/08/2002 - "Concurrent alpha-Toc, TBHQ or PG treatment with NaNO2 is likely to induce forestomach tumors in the long term."
01/01/1988 - "Mammary tumor development was reduced by diet containing TMPD, PG, TBMP, TBHQ or GG, although this could be partly due to antioxidant treatment-associated decrease in body wt gain. "
02/01/2013 - "Much of the funding has led to (1) the novel discovery that arsenic activates the Nrf2 pathway by a mechanism different to that of other Nrf2 activators, such as sulforaphane and tert-butylhydroquinone, (2) activation of Nrf2 by chemopreventive compounds protects against arsenic toxicity and carcinogenicity both in vitro and in vivo, (3) constitutive activation of Nrf2 by disrupting Keap1-mediated negative regulation contributes to cancer and chemoresistance, (4) p62-mediated sequestration of Keap1 activates the Nrf2 pathway, and (5) arsenic-mediated Nrf2 activation may be through a p62-dependent mechanism. "
05/23/1995 - "Interestingly, AP-1 DNA binding activity was induced by the phenolic antioxidant tert-butylhydroquinone (BHQ), but the induction of AP-1 transcriptional activity by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by this compound. "
06/01/2008 - "Upregulation of Nrf2 by the small chemical tert-butylhydroquinone (tBHQ) also enhanced the resistance of cancer cells, indicating the feasibility of using small chemical inhibitors of Nrf2 as adjuvants to chemotherapy to increase the efficacy of chemotherapeutic agents. "
3. Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
4. Neuroblastoma
5. Pheochromocytoma

Related Drugs and Biologics

1. 2-tert-butylhydroquinone (tert-butylhydroquinone)
2. Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
3. Tetrachlorodibenzodioxin (TCDD)
4. Arsenic
5. Estrogen Receptor Modulators (Antiestrogen)
6. Protein Isoforms (Isoforms)
7. Oxidopamine (6 Hydroxydopamine)
8. Glucuronosyltransferase (UDP Glucuronosyltransferase)
9. Sodium Fluoride (Ossin)
10. Estradiol (Estrace)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Oral Administration
3. Aftercare (After-Treatment)
4. Intraperitoneal Injections