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aminomethyltrioxsalen
Also Known As:
(3H)4'-aminomethyl-4,5',8-trimethylpsoralen; 3-(aminomethyl)-2,5,9-trimethyl-7H-furo(3,2-g)(1)benzopyran-7-one; 3H-AMT; 4'-aminomethyl-4,5',8-trimethylpsoralen; 5-AMTP; aminomethylpsoralen; aminomethyltrimethylpsoralen; aminomethyltrioxsalen hydrochloride
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Coumarins: 826
Furocoumarins: 490
Trioxsalen: 95
aminomethyltrioxsalen: 4
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Coumarins: 826
Furocoumarins: 490
Trioxsalen: 95
aminomethyltrioxsalen: 4
3-Ring Heterocyclic Compounds
Furocoumarins: 490
Trioxsalen: 95
aminomethyltrioxsalen: 4
Related Diseases
1.
Vesicular Stomatitis
02/01/1981 - "
Cross-linking of viral RNA by 4'-aminomethyl-4,5',8-trimethylpsoralen in HeLa cells infected with encephalomyocarditis virus and the tsG114 mutant of vesicular stomatitis virus.
"
09/01/1994 - "
It has previously been demonstrated that, during the inactivation of cell-free vesicular stomatitis virus (VSV) by aminomethyltrimethylpsoralen (AMT) and UVA in PCs, platelet function could be protected either by oxygen removal before irradiation or by inclusion of a type I free radical quencher, such as mannitol.
"
2.
Photosensitivity Disorders (Photodermatitis)
04/01/1993 - "
An action spectrum for the relaxation of supercoiled plasmid DNA (induction of the first single-strand break) by photoactivated 4'-aminomethyl-4,5',8-trimethylpsoralen (AMT) has been determined using monochromatic UV photons from 254 to 405 nm. The spectrum of AMT-induced plasmid DNA relaxation fits closely with the absorbance spectrum of AMT in the spectral region between 313 nm and 405 nm but deviates at wavelengths shorter than 313 nm. This assay also reveals that the psoralen photosensitization reaction with DNA also produces piperidine-labile sites.
"
3.
Acute Erythroblastic Leukemia (Erythroleukemia)
05/01/1986 - "
The 4.5S RNA can be cross-linked in vivo by 4'-aminomethyl-4,5',8-trimethylpsoralen to murine erythroleukemia cell poly(A)-terminated cytoplasmic RNA contained in ribonucleoprotein particles.
"
Related Drugs and Biologics
1.
Viral RNA
2.
RNA (Ribonucleic Acid)
3.
Ribonucleoproteins
4.
Poly A
5.
Oxygen (Dioxygen)
6.
Mannitol (Osmitrol)
7.
Free Radicals
8.
Ficusin (Psoralen)
9.
DNA (Deoxyribonucleic Acid)
10.
4.5S RNA