HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
valyl-leucyl-lysine 4-nitroanilide
chromogenic substrate of plasmin; H-D-Val-Leu-Lys- 4-nitroaniline
Also Known As:
S 2251; S-2251; Val-Leu-Lys 4-nitroanilide; valyl-leucyl-lysine 4-nitroanilide, dihydrochloride; L-Lysinamide, D-valyl-L-leucyl-N-(4-nitrophenyl)-, dihydrochloride
Networked:
7
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
valyl-leucyl-lysine 4-nitroanilide: 7
Experts
1.
González, L R
: 1 article (08/2004)
2.
López, M
: 1 article (08/2004)
3.
Pujol, V
: 1 article (08/2004)
4.
Reyes, N
: 1 article (08/2004)
5.
Sotolongo, J
: 1 article (08/2004)
Related Diseases
1.
Infertility (Sterility)
08/01/2004 - "
Samples were periodically subjected to biological activity assays (S-2251 chromogenic-substrate method or in vitro clot-lysis assay), sodium dodecyl sulphate/polyacrylamide gel electrophoresis (SDS/PAGE), pyrogen and sterility testing, abnormal toxicity screening, organoleptic evaluation, and measurement of residual moisture and pH. Accelerated storage (37 degrees C) data showed biochemical stability of SKr throughout the 6-month study with activity, remaining between 90 and 110% of its nominal value (0.75 x 10(6) IU/mL).
"
2.
Septic Shock (Toxic Shock Syndrome)
01/01/1978 - "
Antiplasmin activity was studied during various stages of lethal canine endotoxin shock by means of assays utilizing a new chromogenic tripeptide derivative (S-2251 AB Kabi Peptide Research Division, Mölndal, Sweden).
"
01/01/1978 - "
Spontaneous plasmin activity and 'fast-reacting' and 'time-dependent' antiplasmin activities were determined during various stages of canine endotoxin shock by means of assays utilizing a chromogenic tripeptide derivative (S-2251, Kabi AB, Peptide Research Division, Mölndal).
"
3.
Sepsis (Septicemia)
01/01/1982 - "
In 119 children, predominantly newborns and babies with sepsis, alpha 2-Antiplasmin was determined by the use of the chromogenic substrate S-2251.
"
4.
Thromboembolism
01/01/1978 - "
The determination of blood fibrinolytic activity by synthetic chromogenic substrate S-2251 in patients with high risk of thromboembolism.
"
5.
Rupture
05/01/1983 - "
To elucidate the possible roles of increased plasminogen activator (PA) in follicular rupture and to investigate whether prostaglandins participate in ovarian PA synthesis in vivo, enzyme activities were sequentially measured by a method using the chromogenic substrate S-2251 in immature rat ovaries primed with pregnant mare serum gonadotrophin (PMSG) followed by human chorionic gonadotrophin (hCG) either alone or with a concurrent injection of indomethacin.
"
Related Drugs and Biologics
1.
Chromogenic Compounds
2.
Sodium
3.
Pyrogens
4.
polyacrylamide
5.
Plasminogen Activators (Plasminogen Activator)
6.
Peptides (Polypeptides)
7.
Antifibrinolytic Agents (Antifibrinolytics)
8.
Prostaglandins
9.
Indomethacin (Indometacin)
10.
Fibrinolysin