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4-methylcatechol

structure

Also Known As:

3,4-dihydroxytoluene

Networked: 23 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Catechols: 121
        4-methylcatechol: 23

Experts

1.	Bolkent, Sehnaz: 2 articles (11/2018 - 01/2018)
2.	Hsieh, Yu-Lin: 2 articles (01/2016 - 12/2009)
3.	Fukuhara, Kayoko: 2 articles (03/2014 - 08/2012)
4.	Ishikawa, Kozo: 2 articles (03/2014 - 08/2012)
5.	Ishikawa, Toshizo: 2 articles (03/2014 - 08/2012)
6.	Kakeda, Takahiro: 2 articles (03/2014 - 08/2012)
7.	Yasuda, Seiko: 2 articles (03/2014 - 08/2012)
8.	Choi, Hyo-Kyoung: 1 article (09/2021)
9.	Chung, Min-Yu: 1 article (09/2021)
10.	Hwang, Jin-Taek: 1 article (09/2021)

Related Diseases

1.	Peripheral Nervous System Diseases (PNS Diseases) 01/01/1995 - "We induced neuropathy in rats by means of ACR injection as an experimental model of the dying-back type of peripheral neuropathy to assess the potential efficacy of 4-methylcatechol (4-MC), a potent stimulator of endogenous nerve growth factor (NGF) synthesis, as a therapeutic agent for the axonal nerve lesion. " 12/01/1999 - "In the present study, we investigated the effects of 4-methylcatechol (4-MC), which stimulates nerve growth factor synthesis and protects against peripheral neuropathies in rats, on BDNF content and mRNA expression in cultured brain cells and in vivo in the rat brain. "
2.	Ototoxicity 01/01/1999 - "4-methylcatechol, a potent inducer of nerve growth factor synthesis, protects spiral ganglion neurons from aminoglycoside ototoxicity--preliminary report." 04/01/2015 - "This study was designed to investigate possible neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity. " 04/01/2015 - "Neurotrophic and antioxidant effects of silymarin comparable to 4-methylcatechol in protection against gentamicin-induced ototoxicity in guinea pigs." 04/01/2015 - "Silymarin exerts superiority over 4-methylcatechol when recommended as protective agent against gentamicin ototoxicity based on its efficient neurotrophic and antioxidant activities."
3.	Chronic Pain 08/01/2012 - "Intracerebroventricular 4-methylcatechol (4-MC) ameliorates chronic pain associated with depression-like behavior via induction of brain-derived neurotrophic factor (BDNF)." 03/05/2014 - "4-Methylcatechol prevents derangements of brain-derived neurotrophic factor and TrkB-related signaling in anterior cingulate cortex in chronic pain with depression-like behavior."
4.	Hyperalgesia 01/01/2016 - "The NGF inducer 4-methylcatechol (4MC) normalized the analgesic effects of PAP; specifically, it reversed the PAP and trkA profiles and relieved mechanical allodynia. "
5.	Insulinoma 11/01/2018 - "The aim of this study was to determine the applying doses of 4-methylcatechol (4-MC) for triggening cell death and decreasing the cell function of rat insulinoma INS-1 beta cells. " 01/01/2018 - "In this study, it was aimed to determine the doses of 4-methylcatechol causing cell death in rat insulinoma β-cells (INS-1), to find out the type of cellular death at these doses, and to investigate the molecular mechanism of cellular death occurring. "

Related Drugs and Biologics

1.	Nerve Growth Factor (NGF)
2.	Brain-Derived Neurotrophic Factor (BDNF)
3.	Antioxidants
4.	Silymarin
5.	Gentamicins (Gentamicin)
6.	Analgesics (Analgesic Drugs)
7.	catechol (pyrocatechol)
8.	Neuroprotective Agents
9.	Messenger RNA (mRNA)
10.	Progesterone