|1.||Ishikawa, Toshizo: 2 articles (03/2014 - 08/2012)|
|2.||Kakeda, Takahiro: 2 articles (03/2014 - 08/2012)|
|3.||Yasuda, Seiko: 2 articles (03/2014 - 08/2012)|
|4.||Fukuhara, Kayoko: 2 articles (03/2014 - 08/2012)|
|5.||Ishikawa, Kozo: 2 articles (03/2014 - 08/2012)|
|6.||Pan, Pan: 1 article (08/2015)|
|7.||Young, Matthew R: 1 article (08/2015)|
|8.||Stirdivant, Steven M: 1 article (08/2015)|
|9.||Huang, Yi-Wen: 1 article (08/2015)|
|10.||Stoner, Gary D: 1 article (08/2015)|
|1.||Peripheral Nervous System Diseases (PNS Diseases)
01/01/1995 - "We induced neuropathy in rats by means of ACR injection as an experimental model of the dying-back type of peripheral neuropathy to assess the potential efficacy of 4-methylcatechol (4-MC), a potent stimulator of endogenous nerve growth factor (NGF) synthesis, as a therapeutic agent for the axonal nerve lesion. "
12/01/1999 - "In the present study, we investigated the effects of 4-methylcatechol (4-MC), which stimulates nerve growth factor synthesis and protects against peripheral neuropathies in rats, on BDNF content and mRNA expression in cultured brain cells and in vivo in the rat brain. "
08/01/2012 - "Intracerebroventricular 4-methylcatechol (4-MC) ameliorates chronic pain associated with depression-like behavior via induction of brain-derived neurotrophic factor (BDNF)."
03/05/2014 - "BDNF is induced in cultured neurons by 4-methylcatechol (4-MC), but little is known about its role in pain-emotion. "
03/05/2014 - "4-Methylcatechol prevents derangements of brain-derived neurotrophic factor and TrkB-related signaling in anterior cingulate cortex in chronic pain with depression-like behavior."
08/01/2012 - "BDNF is induced in cultured neurons by 4-methylcatechol (4-MC), but the role of 4-MC-induced BDNF in pain-emotion is poorly understood. "
|3.||Diabetic Neuropathies (Diabetic Neuropathy)
01/01/2011 - "In this study, we investigated the in vivo effects of combined administration of 4-methylcatechol (4-MC) and progesterone (P) as a potential therapeutic tool for sciatic nerve function improvement and its role in histomorphological alterations in diabetic neuropathy in rats. "
03/01/1994 - "The therapeutic effects of 4-methylcatechol, a stimulator of endogenous nerve growth factor synthesis, on experimental diabetic neuropathy in rats."
03/01/1994 - "We investigated therapeutic effects of 4-methylcatechol (4-MC), a non-amine catechol compound, on streptozotocin (STZ)-induced diabetic neuropathy in rats. "
01/01/2011 - "The Effect of Co-administration of 4-Methylcatechol and Progesterone on Sciatic Nerve Function and Neurohistological Alterations in Streptozotocin-Induced Diabetic Neuropathy in Rats."
08/01/2015 - "Increased levels of 4-methylcatechol sulfate in both post-BRB urine and post-BRB plasma were significantly correlated with a higher level of apoptotic marker (TUNEL) in post-BRB tumors. "
07/01/2003 - "To address the inconsistency between its in vivo and in vitro actions, the effect of 4-methylcatechol on the viabilities of murine tumor cells was examined, and 4-methylcatechol was shown to reduce their viabilities through the induction of apoptosis. "
07/01/2003 - "However, 4-methylcatechol, a metabolite produced in the intestinal tract after ingestion, has been shown to cause the promotion rather than suppression of tumor in rat stomach despite its in vitro cytotoxic activity. "
07/01/2003 - "In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: induction of apoptotic cell death by extracellular pro-oxidant action."
07/01/2003 - "These findings indicate that, similar to other catechol compounds, 4-methylcatechol may induce the apoptotic death of murine tumor cells through its extracellular pro-oxidant action on the cells."
|1.||Nerve Growth Factor (NGF)
|2.||Brain-Derived Neurotrophic Factor (BDNF)
|4.||Messenger RNA (mRNA)