|1.||Sleat, David E: 6 articles (12/2012 - 11/2006)|
|2.||Lobel, Peter: 6 articles (12/2012 - 11/2006)|
|3.||Morales, Carlos R: 4 articles (04/2009 - 12/2003)|
|4.||Zheng, Haiyan: 3 articles (12/2012 - 03/2007)|
|5.||Canuel, Maryssa: 3 articles (04/2009 - 12/2003)|
|6.||Lloyd-Evans, Emyr: 2 articles (01/2015 - 08/2003)|
|7.||Butler, Lisa M: 2 articles (12/2014 - 05/2014)|
|8.||Brooks, Doug A: 2 articles (12/2014 - 05/2014)|
|9.||Parkinson-Lawrence, Emma J: 2 articles (12/2014 - 05/2014)|
|10.||Węgrzyn, Alicja: 2 articles (03/2014 - 04/2012)|
|1.||Neurodegenerative Diseases (Neurodegenerative Disease)
09/01/2012 - "Studies of lysosomal proteins linked to neurodegenerative disorders present an opportunity to uncover specific molecular mechanisms and pathways that contribute to neurodegeneration. "
06/01/2012 - "To this end, studies of neurodegenerative disorders caused by mutations in lysosomal proteins offer an opportunity to elucidate such mechanisms and potentially identify specific therapeutic targets. "
02/12/2010 - "The rare neurodegenerative disease Niemann-Pick Type C (NPC) results from mutations in either NPC1 or NPC2, which are membrane-bound and soluble lysosomal proteins, respectively. "
08/01/2010 - "Lysosomal storage diseases (LSDs) are a group of inherited metabolic neurodegenerative disorders due to deficiency of a specific protein integral to lysosomal function, such as enzymes or lysosomal components, or to errors in enzyme trafficking/targeting and defective function of nonenzymatic lysosomal proteins, all preventing the complete degradation and recycling of macromolecules. "
08/08/2003 - "In the gangliosidoses, gangliosides accumulate because of defective activity of the lysosomal proteins responsible for their degradation, usually resulting in a rapidly progressive neurodegenerative disease. "
|2.||Gaucher Disease (Gaucher's Disease)
01/01/2002 - "In this study the relationship among genotype, glycolipid substrates, lysosomal proteins, and the clinical manifestations of Gaucher disease has been evaluated. "
06/17/1991 - "Genetic defects in either of these lysosomal proteins cause phenotypically similar disorders in man, the Gaucher disease. "
10/01/2005 - "This study shows that the lysosomal compartment of human ovarian carcinoma cells selected for stable resistance to CDDP is markedly reduced in size, and that these cells abnormally sort some lysosomal proteins and the putative CDDP transporters into an exosomal pathway that also exports CDDP."
|5.||Lysosomal Storage Diseases (Lysosomal Storage Disease)
01/01/2015 - "Lysosomal storage diseases (LSDs) is a group consisting of over 50 disorders caused mostly by dysfunctions of lysosomal proteins and resultant accumulation of particular compounds inside cells and extracellular volumes in affected organisms. "
01/01/2015 - "Such phenotypes are often associated with the lysosomal storage diseases but are increasingly being observed under conditions where lysosomal proteins or, in some cases, cellular functions associated with lysosomal proteins are being manipulated. "
03/01/2014 - "Lysosomal storage diseases are inherited metabolic disorders caused by genetic defects causing deficiency of various lysosomal proteins, and resultant accumulation of non-degraded compounds. "
01/01/2014 - "Functional deficiencies in lysosomal proteins due to genetic mutations have been found in more than 50 lysosomal storage diseases that exhibit characteristic lipid/macromolecule accumulation and enlarged lysosomes. "
01/01/2013 - "This chapter summarizes our current knowledge of lysosomes and lysosomal proteins referring to recent reviews, general schemes for degradation of substrates, and various causes of lysosomal storage diseases (LSDs). "
|2.||Proteins (Proteins, Gene)
|4.||Lysergic Acid Diethylamide (LSD)
|6.||N-sulfoglucosamine sulfohydrolase (sulfamidase)