glucose-regulated proteins

01/01/2022 - "Our present study not only identified 27HC, a characteristic component of the neoplastic microenvironment of HCC that causes MDR via GRP75 to regulate the redox balance and metabolic reprogramming, but also revealed that targeted intervention by the "switch"-like molecule GRP75 could reverse the effect of 27HC from cancer promotion to cytotoxicity in HCC, suggesting a new strategy for specific intervention of HCC."
01/01/2020 - "Our study revealed that that GRP94 expression in lung AD favors tumor progression and predicts poor prognosis. "
08/29/2017 - "In this study, GRP75, a mitochondria matrix chaperone, was discovered to be highly expressed in mitotic cancer cells. "
04/01/2016 - "In vitro and in vivo studies showed that silencing GRP94 suppressed cancer progression. "
03/15/2012 - "In conclusion, this study suggests that GRP94 overexpression may be a hallmark of aggressiveness and recurrence in breast cancers."

11/01/2022 - "Taken together, our results are in line with the notion that neurons in C9ORF72-ALS/FTD are particularly susceptible to ER-mitochondrial dysfunction and that GRP75 serves as a critical endogenous neuroprotective factor. "
11/01/2022 - "In C9orf72 rodent neurons, an abrupt reduction in GRP75 expression coincided with the onset of UPR, mitochondrial dysfunction and the emergence of PolyGA aggregates, which co-localize with GRP75. "
01/01/2021 - "Furthermore, Aβ treatment increased the expression and interaction of IP3R, Grp75, and vdac1 and led to an increased endoplasmic reticulum (ER)-mitochondria association, malfunction of mitochondria-associated ER-membranes (MAMs), and mitochondrial dysfunction. "
01/01/2017 - "In the present study, we show that genetic ablation of GRP75, by weakening ER-mitochondrial junctions, provided protection against mitochondrial dysfunction and cell death in a model of glutamate-induced oxidative stress. "
03/06/2021 - "Furthermore, the importance of ER stress or GRP75 activity in the apoE4 (Δ272-299)-promoted mitochondrial dysfunction in neuron was investigated. "

01/01/2021 - "A GRP94 IS (immune score) was generated from breast tumors in Chinese women by multiplying the staining intensity and the percentage of positive cells. "
01/01/2021 - "Comprehensive analysis reveals GRP94 is associated with worse prognosis of breast cancer."
01/01/2020 - "GRP94 ablation was performed in a BM model BR-eGFP-CMV/Luc-V5CA1 (BRV5CA1) of breast cancer. "
01/01/2020 - "Expression of GRP94 is associated with cellular transformation and increased tumorigenicity in breast cancer. "
01/01/2018 - "Furthermore, patients with breast cancer tissue that expressed high GRP94 had a significantly shorter survival time than did patients with a low GRP94 expression (P<0.001). "

01/01/2018 - "In conclusion, miR‑150 may serve a protective role in cardiomyocyte hypoxia injury, and the underlying mechanism was mediated, at least partially, by inhibiting GRP94 expression. "
01/03/2005 - "Three putative hypoxia responsive elements (HRE) were found in the GRP94 promoter. "
08/01/2003 - "Here, we report that expression of GRP94 was increased in human neuroblastoma cells (SH-SY5Y (SY5Y) cells) exposed to hypoxia/reoxygenation (H/R). "
01/01/2020 - "Extensive studies in mammals showed that GRP75 is induced by various stressors such as glucose deprivation, oxidative stress, and hypoxia, although it remained unresponsive to the heat shock. "
01/01/2020 - "Mitochondrial Translocation of DJ-1 Is Mediated by Grp75: Implication in Cardioprotection of Resveratrol Against Hypoxia/Reoxygenation-Induced Oxidative Stress."

09/01/2005 - "This study examined the involvement of GRP94 in radio-resistance in human cervical cancer cells. "
01/01/2014 - "Glucose-regulated protein 94 modulates the therapeutic efficacy to taxane in cervical cancer cells."
01/01/2014 - "Therefore, we conclude that silencing GRP94 may increase resistance to taxane treatment in cervical cancer cells by altering the activation of the apoptosis pathway. "
09/01/2005 - "High basal protein levels of GRP94 were correlated with a modest decrease in sensitivity to X-ray cell death in some cervical cancer cell lines. "
09/01/2005 - "Increased expression of GRP94 protein is associated with decreased sensitivity to X-rays in cervical cancer cell lines."