falcarinol

an acetylenic hydrocarbon, similar to cicutoxin, derived from oleic acid in Araliaceae, Umbelliferae and other plants; RN given refers to (R-(Z))-isomer; it can cause contact dermatitis in some individuals; panaxynol is the 3,4-cis-8,9-trans isomer of falcarinol

Also Known As:

Networked: 43 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kobaek-Larsen, Morten: 4 articles (01/2020 - 03/2005)
2.	Christensen, Lars P: 4 articles (01/2011 - 03/2005)
3.	Baatrup, Gunnar: 3 articles (01/2020 - 06/2018)
4.	Christensen, Lars Porskjær: 3 articles (01/2020 - 06/2018)
5.	Park, Jeong Hill: 3 articles (12/2019 - 01/2018)
6.	Hofseth, Lorne J: 2 articles (06/2020 - 06/2015)
7.	Nagarkatti, Mitzi: 2 articles (06/2020 - 06/2015)
8.	Nagarkatti, Prakash: 2 articles (06/2020 - 06/2015)
9.	Windust, Anthony: 2 articles (06/2020 - 06/2015)
10.	Bakovic, Marica: 2 articles (01/2020 - 01/2018)

Related Diseases

1.	Reperfusion Injury 08/01/2023 - "Panaxynol ameliorates cardiac ischemia/reperfusion injury by suppressing NLRP3-induced pyroptosis and apoptosis via HMGB1/TLR4/NF-κB axis."
2.	Colonic Neoplasms (Colon Cancer) 02/07/2007 - "The polyacetylene falcarinol, isolated from carrots, has been shown to be protective against chemically induced colon cancer development in rats, but the mechanisms are not fully understood. "
3.	Inflammation (Inflammations) 10/01/2023 - "Panaxynol alleviates colorectal cancer in a murine model via suppressing macrophages and inflammation." 01/26/2023 - "In vitro studies and animal studies have shown that chemical compounds contained in carrots, such as falcarinol and falcarindiol, can prevent inflammation. " 01/01/2020 - "The aim of this study was to investigate the hypothesis that polyacetylene falcarinol (FA) reduces intestinal inflammation and examine its similarity of effect to isothiocyanate R-sulforaphane during the late phase of acute inflammation. " 09/14/2019 - "Dietary Polyacetylenic Oxylipins Falcarinol and Falcarindiol Prevent Inflammation and Colorectal Neoplastic Transformation: A Mechanistic and Dose-Response Study in A Rat Model." 02/05/2018 - "Reactive oxygen species have critical roles in the reduction in HMW adiponection secretion by palmitic acid; however, panaxynol reduced this increase in reactive oxygen species generation, followed by reductions in markers of endoplasmic reticulum stress and inflammation. "
4.	Neoplasms (Cancer) 01/01/2011 - "In addition, the cytotoxicity of falcarinol type polyacetylenes towards human cancer cells, bioavailability, and their potential anticancer effect in vivo indicates that these compounds may contribute to the health effects of certain vegetables and hence could be important nutraceuticals. " 03/09/2005 - "This indicates that the dietary treatments with carrot and falcarinol delayed or retarded the development of large ACF and tumors. " 01/01/2002 - "Cell-cycle analysis indicated that panaxynol arrested the cell cycle progression of tumor cells from the G1 transition to the S phase. " 01/01/2002 - "On a percentage basis, panaxynol purified from Saposhnikovae divaricata had the highest inhibitory activity on various tumor cells proliferation. " 03/01/1993 - "Using this assay we reconfirmed the rapid consumption of panaxynol by target tumor cells in an in vitro-culture system. "
5.	Breast Neoplasms (Breast Cancer) 01/15/2014 - "Dietary polyacetylenes of the falcarinol type are inhibitors of breast cancer resistance protein (BCRP/ABCG2)." 01/15/2014 - "In this study, falcarinol, falcarindiol, falcarindiol 3-acetate and falcarindiol 3,8-diacetate were examined for their modulation on breast cancer resistance protein (BCRP/ABCG2), an efflux transporter important for xenobiotic absorption and disposition, and multidrug resistance in cancer. "

Related Drugs and Biologics

1.	HMGB1 Protein (HMG1)
2.	falcarindiol
3.	Oxylipins
4.	panaxydol
5.	Messenger RNA (mRNA)
6.	sulforaphane
7.	Xenobiotics
8.	Proteins (Proteins, Gene)
9.	isothiocyanic acid
10.	Heme Oxygenase-1

Related Therapies and Procedures

1.	Chemoprevention