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6-ethyl-3-(1H-tetrazol-5-yl)chromone
antiallergic agent; structure
Also Known As:
AA 344; AA-344; 6-ethyl-3-(1H-tetrazol-5-yl)-4H-1-benzopyran-4-one
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrans: 130
Benzopyrans: 195
Chromones: 159
6-ethyl-3-(1H-tetrazol-5-yl)chromone: 3
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzopyrans: 195
Chromones: 159
6-ethyl-3-(1H-tetrazol-5-yl)chromone: 3
Related Diseases
1.
Hypersensitivity (Allergy)
10/01/1979 - "
The results indicate that AA-344 selectively suppresses the type I allergic reaction.
"
10/01/1979 - "
Effects of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) on the experimental models of the type I-IV allergic reactions were studied in comparison with those of disodium cromoglycate (DSCG), dexamethasone and other agents.
"
01/01/1980 - "
AA-344, which has been evidenced to inhibit selectively IgE-mediated allergic reactions, exhibited an inhibitory effect on cyclic AMP phosphodiesterase (PDase) in the homogenates of purified rat peritoneal mast cells (RMC).
"
01/01/1980 - "
These results obtained in vitro suggest that AA-344 may exert antiallergic action by increasing cyclic AMP via an interaction with epinephrine or prostaglandins which might be endogenously involved in regulation of a function of RMC in allergic reactions.
"
2.
Immediate Hypersensitivity
06/01/1979 - "
These results indicate that the inhibitory action of AA-344 on the immediate hypersensitivity reactions is due to prevention of the release of chemical mediators from the mast cells, by acting on some process in sequential events leading to the mediator release following antigen-antibody combination.
"
3.
Delayed Hypersensitivity (Hypersensitivity, Type IV)
10/01/1979 - "
Effect of 6-ethyl-3-(1H-tetrazol-5-yl)chromone (AA-344) on the immediate and delayed hypersensitivity reactions.
"
4.
Anaphylaxis (Anaphylactic Shock)
10/01/1979 - "
AA-344 showed inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs.
"
Related Drugs and Biologics
1.
Anti-Allergic Agents (Antiallergic Agents)
2.
Prostaglandins
3.
Phosphoric Diester Hydrolases (Phosphodiesterases)
4.
Immunoglobulin E (IgE)
5.
Epinephrine (Adrenaline)
6.
Cromolyn Sodium (Cromoglicic Acid)
7.
Dexamethasone (Maxidex)
8.
Antigens
9.
Cyclic AMP (AMP, Cyclic)