cinromide

03/01/1982 - "These data suggest that cinromide should be clinically effective, not only against tonic-clonic seizures, but also, toxicity permitting, against complex partial attacks as well."
01/01/2021 - "We found very low-certainty evidence that 35 more people per 1000 (CI 123 fewer to 434 more) had 50% or greater average reduction of overall seizures with add-on cinromide compared to add-on placebo (one study; 56 participants; RR 1.15, 95% CI 0.47 to 2.86). "
08/01/1983 - "This study did not demonstrate a beneficial effect of cinromide over placebo for Type A, B, or C partial seizures. "
01/01/1988 - "Cinromide was also able to suppress this type of seizures, but in adult rats the dose of 75 mg.kg-1 had to be administered because even the 50 mg.kg-1 dose was not sufficient. "
01/01/1988 - "Cinromide was efficient against this type of seizures at all developmental stages, but its action in 7- and especially in 12-day-old rat pups was less marked than in older animals. "

07/01/1989 - "This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome. "
07/01/1989 - "The Group for the Evaluation of Cinromide in the Lennox-Gastaut Syndrome."
07/01/1989 - "Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut Syndrome. "

08/01/1983 - "A double-blind controlled trial of cinromide in 25 adult subjects with refractory epilepsy using the maximum tolerated dose showed that it possessed no significant antiepileptic properties."

08/01/1983 - "Cinromide in epilepsy: a pilot study."
08/01/1983 - "Cinromide has previously been shown to have significant antiepileptic activity in various animal models of epilepsy. "

08/01/1983 - "Monotherapy with the experimental antiepileptic drug cinromide was evaluated in 11 adult outpatients with uncontrolled partial epilepsy. "