HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
spiroxatrine
structure
Also Known As:
8-(1,4-benzodioxan-2-ylmethyl)-1-phenyl-1,3,8-triazaspiro(4,5)-decan-4-one; R 5188
Networked:
7
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Dioxanes
spiroxatrine: 7
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Spiro Compounds: 2
spiroxatrine: 7
Polycyclic Compounds: 6
Spiro Compounds: 2
spiroxatrine: 7
Experts
1.
Liu, Z-Y
: 1 article (01/2002)
2.
Lunderberg, T
: 1 article (01/2002)
3.
Yu, L-C
: 1 article (01/2002)
4.
Zhuang, D-B
: 1 article (01/2002)
Related Diseases
1.
Bradycardia
02/01/1990 - "
8-OH-DPAT (0.0625-4.0 micrograms) produced dose-dependent hypotension and bradycardia, which were antagonized by the 5-HT1A antagonists spiperone and spiroxatrine.
"
08/21/1987 - "
Bradycardia was not susceptible to ketanserin and cocaine (for 5-MeODMT) or to ketanserin and methysergide (for 8-OH-DPAT) but to methysergide and spiroxatrine (for 5-MeODMT) and cocaine and spiroxatrine (for 8-OH-DPAT).
"
2.
Ocular Hypotension
08/01/1999 - "
DPAT-induced ocular hypotension was inhibited by pretreatment with spiroxatrine, a 5-HT(1A)and alpha(2C)receptor antagonist, but not spiperone, a 5-HT(2A)receptor antagonist.
"
08/01/1999 - "
These findings indicate that: (1) based upon bilateral activity by the topical route, DPAT-induced ocular hypotension could result, in part, through activation of 5-HT(1A)receptors in the eye and 5-HT(1A)receptors and/or alpha(2C)adrenoreceptors in the central nervous system, (2) the activity of DPAT on 5-HT(1A)and/or alpha(2C)receptors was confirmed by antagonism of the ocular hypotensive response by spiroxatrine, (3) although there is no apparent prejunctional effect of DPAT on sympathetic nerves of iris-ciliary bodies, the accumulation of basal and isoproterenol-stimulated cAMP levels were depressed by DPAT, and (4) as a result of inhibition by rauwolscine, the ocular hypotensive effect of DPAT in the contralateral eye could involve an action on alpha(2)adrenoreceptors in the central nervous system.
"
3.
Tachycardia (Tachyarrhythmias)
01/01/1992 - "
The 5-HT1 receptor antagonists, pindolol and spiroxatrine, the 5-HT3 receptor antagonist MDL 72222 and the alpha 2-adrenoceptor blocking agent idazoxan failed to antagonize the tachycardia induced by 5-HT.
"
4.
Inflammation (Inflammations)
01/01/2002 - "
Furthermore, intrathecal administration of spiroxatrine, but not RS 102221 nor MDL 72222, significantly attenuated the increased hindpaw withdrawal latencies induced by intra-periaqueductal gray administration of morphine in rats with nerve injury and in rats with inflammation.
"
5.
Hypotension (Low Blood Pressure)
02/01/1990 - "
8-OH-DPAT (0.0625-4.0 micrograms) produced dose-dependent hypotension and bradycardia, which were antagonized by the 5-HT1A antagonists spiperone and spiroxatrine.
"
Related Drugs and Biologics
1.
Spiperone
2.
Serotonin (5 Hydroxytryptamine)
3.
bemesetron
4.
5-HT3 Serotonin Receptors (5 HT3 Receptor)
5.
5-HT1 Serotonin Receptors
6.
Idazoxan
7.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
8.
Yohimbine (Yocon)
9.
Pindolol (LB 46)
10.
Morphine (MS Contin)