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pregnenolone sulfate

RN given refers to (3 beta)-isomer
Also Known As:
5-pregnen-3 beta-ol-20-one sulfate; pregnenolone sulfate, (3alpha)-isomer; pregnenolone sulfate, sodium salt, (3beta)-isomer
Networked: 37 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Müller, Isabelle: 3 articles (05/2014 - 03/2011)
2. Thiel, Gerald: 3 articles (05/2014 - 03/2011)
3. Rössler, Oliver G: 2 articles (05/2014 - 12/2011)
4. Kostakis, Emmanuel: 2 articles (08/2013 - 11/2011)
5. Jang, Ming-Kuei: 2 articles (08/2013 - 11/2011)
6. Gibbs, Terrell T: 2 articles (08/2013 - 11/2011)
7. Farb, David H: 2 articles (08/2013 - 11/2011)
8. Russek, Shelley J: 2 articles (08/2013 - 11/2011)
9. Porcu, Patrizia: 2 articles (07/2009 - 02/2008)
10. Szyndler, J: 2 articles (08/2004 - 10/2000)

Related Diseases

1. Amnesia (Dissociative Amnesia)
2. Schizophrenia (Dementia Praecox)
3. Seizures (Seizure)
08/01/2004 - "The aim of the present study was to analyze biochemical effects of a neurosteroid, pregnenolone sulfate (PS), which accompany changes in the threshold of seizures, and to establish the contribution of local, hippocampal monoaminergic and amino acid systems, to the control of convulsive activity. "
03/12/1998 - "Four weeks of subcutaneous treatment with pregnenolone sulfate and dehydroepiandrosterone sulfate, at a dose of 10 mg kg(-1) day(-1), significantly shifted the pentylenetetrazol dose-percent convulsions and latency curves to the left, and markedly decreased the ED50 of pentylenetetrazol for tonic convulsions, indicating the increased sensitivity of mice to seizures. "
03/12/1998 - "We have investigated the effects of chronic treatment with the neurosteroids, pregnenolone sulfate and dehydroepiandrosterone sulfate, on the potential neurotoxicity in pentylenetetrazol seizure sensitivity test in mice. "
09/04/1992 - "In agreement with previous in vitro reports showing that the glutamergic NMDA receptor is also specifically modulated by steroids, our findings suggest that pregnenolone sulfate selectively activates the NMDA receptors involved in convulsions in the intact animal."
11/01/1997 - "We found that 5 alpha-pregnan-3 alpha-ol-20-one (allopregnanolone; 10 and 20 mg/kg) markedly elevated CD50 for kainate-induced convulsions, whereas 5 beta-pregnan-3 alpha-ol-20-one, 5 alpha-pregnan-3 alpha-ol-11,20-dione, 5 alpha-androstan-3 alpha-ol-17-one, dehydroepiandrosterone sulfate, pregnenolone sulfate and aminosteroid (U-107) were ineffective in that test. "
4. Vertigo (Positional Vertigo)
5. Psychomotor Agitation (Akathisia)

Related Drugs and Biologics

1. Pregnanolone (Allopregnanolone)
2. Neurotransmitter Agents (Neurotransmitter)
3. Pregnenolone
4. Dehydroepiandrosterone (DHEA)
5. tetrahydrodeoxycorticosterone
6. Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)
7. 5-alpha-Dihydroprogesterone (5 alpha-Dihydroprogesterone)
8. sigma Receptors (sigma Receptor)
9. GABA-A Receptors (GABA(A) Receptor)
10. Chloralose

Related Therapies and Procedures

1. Intraperitoneal Injections